(2S,3S)-N-(t-butoxycarbonyl)-4-diphenylphosphinyl-2-diphenylphosphinylmethylpyrrolidine

Base Information

• Chemical Name: (2S,3S)-N-(t-butoxycarbonyl)-4-diphenylphosphinyl-2-diphenylphosphinylmethylpyrrolidine
• CAS No.: 96332-73-9
• Molecular Formula: C₃₄H₃₇NO₄P₂
• Molecular Weight: 585.62
• Mol file: 96332-73-9.mol

Synonyms:(2S,3S)-N-(t-butoxycarbonyl)-4-diphenylphosphinyl-2-diphenylphosphinylmethylpyrrolidine

Chemical Property of (2S,3S)-N-(t-butoxycarbonyl)-4-diphenylphosphinyl-2-diphenylphosphinylmethylpyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3S)-N-(t-butoxycarbonyl)-4-diphenylphosphinyl-2-diphenylphosphinylmethylpyrrolidine

There total 1 articles about (2S,3S)-N-(t-butoxycarbonyl)-4-diphenylphosphinyl-2-diphenylphosphinylmethylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(2S,4S)-N-butoxycarbonyl-4-diphenylphosphino-2-diphenylphosphinomethylpyrrolidine (61478-28-2) → (2S,3S)-N-(t-butoxycarbonyl)-4-diphenylphosphinyl-2-diphenylphosphinylmethylpyrrolidine (96332-73-9)

Guidance literature:

With dihydrogen peroxide; In acetone;

DOI:10.1248/cpb.42.481

Reference yield: 98.0%

(2S,3S)-N-(t-butoxycarbonyl)-4-diphenylphosphinyl-2-diphenylphosphinylmethylpyrrolidine (96332-73-9) → (2S,4S)-4-(Diphenyl-phosphinoyl)-2-(diphenyl-phosphinoylmethyl)-pyrrolidine; hydrochloride

Guidance literature:

With hydrogenchloride; In methanol;

DOI:10.1248/cpb.42.481

Reference yield:

(2S,3S)-N-(t-butoxycarbonyl)-4-diphenylphosphinyl-2-diphenylphosphinylmethylpyrrolidine (96332-73-9) → (2S,3S)-4-dicyclohexylphosphinyl-2-dicyclohexylphosphinylmethylpyrrolidine (96332-75-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / 3percent HCl / methanol

2: 91 percent / H₂, 5percent Rh on Al₂O₃ / methanol

With hydrogenchloride; rhodium on alumina; hydrogen; In methanol;

DOI:10.1248/cpb.42.481

upstream raw materials:

(2S,4S)-N-butoxycarbonyl-4-diphenylphosphino-2-diphenylphosphinomethylpyrrolidine

Downstream raw materials:

(2S,3S)-4-dicyclohexylphosphinyl-2-dicyclohexylphosphinylmethylpyrrolidine

(2S-cis)-4-(dicyclohexylphosphino)-2-<(dicyclohexylphosphino)methyl>-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester

(2S,cis)-4-(dicyclohexylphosphino)-2-<(dicyclohexylphosphino)methyl>pyrrolidine

Refernces

• 1、 Tani, Kazuhide,Suwa, Kenichi,Tanigawa, Eiji,Ise, Tomokazu,Yamagata, Tsuneaki,et al.. "Preparation of optically active peralkyldiphosphines and their use, as the rhodium(I) complex, in the asymmetric catalytic hydrogenation of ketones". . p. 203 - 222. Retrieved 2007/10/02.