3-chloro-5-((1-((5-(1-fluoroethyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

Base Information

Chemical Name:3-chloro-5-((1-((5-(1-fluoroethyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile
CAS No.:1591824-01-9
Molecular Formula:C₁₉H₁₂ClF₄N₅O₃
Molecular Weight:469.783
Hs Code.:

Synonyms:3-chloro-5-((1-((5-(1-fluoroethyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

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Chemical Property of 3-chloro-5-((1-((5-(1-fluoroethyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

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Technology Process of 3-chloro-5-((1-((5-(1-fluoroethyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

There total 15 articles about 3-chloro-5-((1-((5-(1-fluoroethyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1591823-99-2
3-chloro-5-((1-((5-(1-hydroxyethyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

: 1591824-01-9
3-chloro-5-((1-((5-(1-fluoroethyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane;

Reference yield:

: 1591827-20-1
methyl 5-(tert-butoxymethyl)-6-methoxypyridazine-3-carboxylate

: 1591824-01-9
3-chloro-5-((1-((5-(1-fluoroethyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

Guidance literature:: Multi-step reaction with 8 steps

1: sodium tetrahydroborate / tetrahydrofuran; methanol

2: dichloromethane

3: N,N-dimethyl-formamide; ethyl acetate

4: trifluoroacetic acid

5: dichloromethane

6: thiophen-2-yl magnesium bromide / tetrahydrofuran

7: acetonitrile

8: diethylamino-sulfur trifluoride / dichloromethane

With sodium tetrahydroborate; diethylamino-sulfur trifluoride; thiophen-2-yl magnesium bromide; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1591827-22-3
(5-(tert-butoxymethyl)-6-methoxypyridazin-3-yl)methanol

: 1591824-01-9
3-chloro-5-((1-((5-(1-fluoroethyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

Guidance literature:: Multi-step reaction with 7 steps

1: dichloromethane

2: N,N-dimethyl-formamide; ethyl acetate

3: trifluoroacetic acid

4: dichloromethane

5: thiophen-2-yl magnesium bromide / tetrahydrofuran

6: acetonitrile

7: diethylamino-sulfur trifluoride / dichloromethane

With diethylamino-sulfur trifluoride; thiophen-2-yl magnesium bromide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;