2-[(Bromoacetyl)amino]-4-(4-chlorophenyl)-1,3-thiazole, N-(Bromoacetyl)-4-(4-chlorophenyl)-1,3-thiazol-2-amine

Base Information

• Chemical Name: 2-[(Bromoacetyl)amino]-4-(4-chlorophenyl)-1,3-thiazole, N-(Bromoacetyl)-4-(4-chlorophenyl)-1,3-thiazol-2-amine
• CAS No.: 448224-88-2
• Molecular Formula: C₁₁H₈BrClN₂OS
• Molecular Weight: 331.62
• Hs Code.: 2934100090
• Mol file: 448224-88-2.mol

Synonyms:2-bromo-N-[4-(4-chloro-phenyl)-1,3-thiazol-2-yl]-acetamide

Chemical Property of 2-[(Bromoacetyl)amino]-4-(4-chlorophenyl)-1,3-thiazole, N-(Bromoacetyl)-4-(4-chlorophenyl)-1,3-thiazol-2-amine

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

N1-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-2-bromoacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(Bromoacetyl)amino]-4-(4-chlorophenyl)-1,3-thiazole, N-(Bromoacetyl)-4-(4-chlorophenyl)-1,3-thiazol-2-amine

There total 4 articles about 2-[(Bromoacetyl)amino]-4-(4-chlorophenyl)-1,3-thiazole, N-(Bromoacetyl)-4-(4-chlorophenyl)-1,3-thiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

4-(4-chlorophenyl)-2-thiazolamine (2103-99-3) + 2-Bromoacetyl bromide (598-21-0) → 2-bromo-N-[4-(4-chloro-phenyl)-1,3-thiazol-2-yl]-acetamide (448224-88-2)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.3109/14756366.2015.1135912

Reference yield:

4-chlorobenzoylmethyl bromide (536-38-9) → 2-bromo-N-[4-(4-chloro-phenyl)-1,3-thiazol-2-yl]-acetamide (448224-88-2)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / Reflux

2: potassium carbonate / 0 - 5 °C

With potassium carbonate; In ethanol;

DOI:10.1016/j.bmc.2021.116168

Reference yield:

para-chloroacetophenone (99-91-2) → 2-bromo-N-[4-(4-chloro-phenyl)-1,3-thiazol-2-yl]-acetamide (448224-88-2)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / 60 - 80 °C

2: ethanol / Reflux

3: potassium carbonate / 0 - 5 °C

With potassium carbonate; toluene-4-sulfonic acid; In ethanol;

DOI:10.1016/j.bmc.2021.116168

upstream raw materials:

4-(4-chlorophenyl)-2-thiazolamine

2-Bromoacetyl bromide

4-chlorobenzoylmethyl bromide

para-chloroacetophenone