2-[(1R,2R)-2-[(diphenylphosphoroso)amino]-1,2-diphenylethyl]-2,3-dihydro-1H-isoindole-1,3-dione

Base Information

• Chemical Name: 2-[(1R,2R)-2-[(diphenylphosphoroso)amino]-1,2-diphenylethyl]-2,3-dihydro-1H-isoindole-1,3-dione
• CAS No.: 1456713-16-8
• Molecular Formula: C₃₄H₂₇N₂O₃P
• Molecular Weight: 542.574

Synonyms:2-[(1R,2R)-2-[(diphenylphosphoroso)amino]-1,2-diphenylethyl]-2,3-dihydro-1H-isoindole-1,3-dione

Chemical Property of 2-[(1R,2R)-2-[(diphenylphosphoroso)amino]-1,2-diphenylethyl]-2,3-dihydro-1H-isoindole-1,3-dione

Chemical Property:

Purity/Quality:

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Technology Process of 2-[(1R,2R)-2-[(diphenylphosphoroso)amino]-1,2-diphenylethyl]-2,3-dihydro-1H-isoindole-1,3-dione

There total 3 articles about 2-[(1R,2R)-2-[(diphenylphosphoroso)amino]-1,2-diphenylethyl]-2,3-dihydro-1H-isoindole-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

2-[(1R,2R)-2-amino-1,2-diphenylethyl]-2,3-dihydro-1H-isoindole-1,3-dione (1387581-28-3) + Diphenylphosphinic chloride (1499-21-4) → 2-[(1R,2R)-2-[(diphenylphosphoroso)amino]-1,2-diphenylethyl]-2,3-dihydro-1H-isoindole-1,3-dione (1456713-16-8)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 4h; Inert atmosphere;

DOI:10.1016/j.tet.2013.12.054

Reference yield:

phthalic anhydride (85-44-9) → 2-[(1R,2R)-2-[(diphenylphosphoroso)amino]-1,2-diphenylethyl]-2,3-dihydro-1H-isoindole-1,3-dione (1456713-16-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; toluene-4-sulfonic acid / toluene / 12 h / Reflux; Inert atmosphere

2: triethylamine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

With potassium carbonate; toluene-4-sulfonic acid; triethylamine; In dichloromethane; toluene;

DOI:10.1016/j.tet.2013.12.054

Reference yield:

(R,R)-1,2-diphenylethylenediamine (35132-20-8) → 2-[(1R,2R)-2-[(diphenylphosphoroso)amino]-1,2-diphenylethyl]-2,3-dihydro-1H-isoindole-1,3-dione (1456713-16-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; toluene-4-sulfonic acid / toluene / 12 h / Reflux; Inert atmosphere

2: triethylamine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

With potassium carbonate; toluene-4-sulfonic acid; triethylamine; In dichloromethane; toluene;

DOI:10.1016/j.tet.2013.12.054

upstream raw materials:

phthalic anhydride

2-[(1R,2R)-2-amino-1,2-diphenylethyl]-2,3-dihydro-1H-isoindole-1,3-dione

Diphenylphosphinic chloride

(R,R)-1,2-diphenylethylenediamine

Downstream raw materials:

[(1R,2R)-2-amino-1,2-diphenylethyl](diphenylphosphoroso)amine

[(1R,2R)-2-[(diphenylphosphoroso)amino]-1,2-diphenylethyl](propan-2-yl)amine

[(1R,2R)-2-(cyclohexylamino)-1,2-diphenylethyl](diphenylphosphoroso)amine

(butan-2-yl)[(1R,2R)-2-[(diphenylphosphoroso)amino]-1,2-diphenylethyl]amine

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