N,2-dimethyl-N-phenylpent-4-ynamide

Base Information

• Chemical Name: N,2-dimethyl-N-phenylpent-4-ynamide
• CAS No.: 1616976-90-9
• Molecular Formula: C₁₃H₁₅NO
• Molecular Weight: 201.268
• Mol file: 1616976-90-9.mol

Synonyms:N,2-dimethyl-N-phenylpent-4-ynamide

Chemical Property of N,2-dimethyl-N-phenylpent-4-ynamide

Chemical Property:

Purity/Quality:

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Technology Process of N,2-dimethyl-N-phenylpent-4-ynamide

There total 1 articles about N,2-dimethyl-N-phenylpent-4-ynamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

N-methyl-N-phenylpropanamide (5827-78-1) + propargyl bromide (106-96-7) → N,2-dimethyl-N-phenylpent-4-ynamide (1616976-90-9)

Guidance literature:

With n-butyllithium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; toluene; at -75 - 20 ℃; Inert atmosphere;

DOI:10.1021/jm5007947

Reference yield: 34.0%

N,2-dimethyl-N-phenylpent-4-ynamide (1616976-90-9) + benzylidene phenylamine (538-51-2) → N,2-dimethyl-N-phenyl-3-(2-phenylquinolin-4-yl)propanamide (1616976-68-1)

Guidance literature:

With silver trifluoromethanesulfonate; copper(l) chloride; In 1,2-dichloro-ethane; at 100 ℃; for 17h; Inert atmosphere;

DOI:10.1021/jm5007947

upstream raw materials:

N-methyl-N-phenylpropanamide

propargyl bromide

Downstream raw materials:

N,2-dimethyl-N-phenyl-3-(2-phenylquinolin-4-yl)propanamide

Refernces