2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-N-[3-(2-{3-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)acetylamino]prop-1-ynyl}phenyl)prop-2-ynyl]acetamide

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Chemical Name:2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-N-[3-(2-{3-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)acetylamino]prop-1-ynyl}phenyl)prop-2-ynyl]acetamide
CAS No.:1400590-83-1
Molecular Formula:C₂₆H₂₄N₆O₆
Molecular Weight:516.513
Hs Code.:

2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-N-[3-(2-{3-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)acetylamino]prop-1-ynyl}phenyl)prop-2-ynyl]acetamide

Synonyms:2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-N-[3-(2-{3-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)acetylamino]prop-1-ynyl}phenyl)prop-2-ynyl]acetamide

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Chemical Property of 2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-N-[3-(2-{3-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)acetylamino]prop-1-ynyl}phenyl)prop-2-ynyl]acetamide

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Technology Process of 2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-N-[3-(2-{3-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)acetylamino]prop-1-ynyl}phenyl)prop-2-ynyl]acetamide

There total 5 articles about 2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-N-[3-(2-{3-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)acetylamino]prop-1-ynyl}phenyl)prop-2-ynyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1400590-82-0
C₃₆H₄₀N₆O₁₀

: 1400590-83-1
2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-N-[3-(2-{3-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)acetylamino]prop-1-ynyl}phenyl)prop-2-ynyl]acetamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 5h; Inert atmosphere;
DOI:10.1016/j.tet.2012.07.093

Reference yield:

: 615-42-9
1,2-Diiodobenzene

: 1400590-83-1
2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-N-[3-(2-{3-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)acetylamino]prop-1-ynyl}phenyl)prop-2-ynyl]acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; copper(l) iodide / 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

4.1: caesium carbonate / acetonitrile / 0.5 h / 20 °C / Inert atmosphere

4.2: 8 h / 20 °C / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; triethylamine; trifluoroacetic acid; In dichloromethane; acetonitrile; 1.1: |Sonogashira Cross-Coupling;
DOI:10.1016/j.tet.2012.07.093

Reference yield:

: 1400590-78-4
{3-[2-(3-tert-butoxycarbonylamino-prop-1-ynyl)phenyl]prop-2-ynyl}carbamic acid tert-butyl ester

: 1400590-83-1
2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-N-[3-(2-{3-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)acetylamino]prop-1-ynyl}phenyl)prop-2-ynyl]acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

3.1: caesium carbonate / acetonitrile / 0.5 h / 20 °C / Inert atmosphere

3.2: 8 h / 20 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

With caesium carbonate; triethylamine; trifluoroacetic acid; In dichloromethane; acetonitrile;
DOI:10.1016/j.tet.2012.07.093