(7RS)-7-benzyloxy-6,11-dimethoxy-2,2-dimethyl-12-methylene-7,12-dihydro-4H-1,3-dioxabenzo[a]anthracene

Base Information

Chemical Name:(7RS)-7-benzyloxy-6,11-dimethoxy-2,2-dimethyl-12-methylene-7,12-dihydro-4H-1,3-dioxabenzo[a]anthracene
CAS No.:808750-14-3
Molecular Formula:C₂₈H₂₈O₅
Molecular Weight:444.527
Hs Code.:

Synonyms:(7RS)-7-benzyloxy-6,11-dimethoxy-2,2-dimethyl-12-methylene-7,12-dihydro-4H-1,3-dioxabenzo[a]anthracene

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Chemical Property of (7RS)-7-benzyloxy-6,11-dimethoxy-2,2-dimethyl-12-methylene-7,12-dihydro-4H-1,3-dioxabenzo[a]anthracene

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Technology Process of (7RS)-7-benzyloxy-6,11-dimethoxy-2,2-dimethyl-12-methylene-7,12-dihydro-4H-1,3-dioxabenzo[a]anthracene

There total 11 articles about (7RS)-7-benzyloxy-6,11-dimethoxy-2,2-dimethyl-12-methylene-7,12-dihydro-4H-1,3-dioxabenzo[a]anthracene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 808750-13-2
(1'RS)-7-[1'-benzyloxy-(2'-iodo-3'-methoxyphenyl)-methyl]-6-methoxy-2,2-dimethyl-8-vinyl-4H-benzo[1,3]dioxine

: 808750-14-3
(7RS)-7-benzyloxy-6,11-dimethoxy-2,2-dimethyl-12-methylene-7,12-dihydro-4H-1,3-dioxabenzo[a]anthracene

Guidance literature:: With tetrabutyl-ammonium chloride; potassium carbonate; triphenylphosphine; palladium diacetate; In N,N-dimethyl-formamide; at 80 ℃; for 12h;
DOI:10.1002/chem.200400342

Reference yield:

: 7-bromo-8-formyl-6-methoxy-2,2-dimethyl-4H-benzo[1,3]dioxine

: 808750-14-3
(7RS)-7-benzyloxy-6,11-dimethoxy-2,2-dimethyl-12-methylene-7,12-dihydro-4H-1,3-dioxabenzo[a]anthracene

Guidance literature:: Multi-step reaction with 4 steps

1.1: t-BuOK / tetrahydrofuran / 1 h / 20 °C

1.2: 87 percent / tetrahydrofuran / 1 h / 20 °C

2.1: t-BuLi / diethyl ether; hexane / 0.17 h / -78 °C

2.2: diethyl ether; hexane / -78 - 20 °C

3.1: 654 mg / NaH / tetrahydrofuran / 12 h / 40 °C

4.1: 85 percent / n Bu₄NCl; K₂CO₃; PPh₃ / Pd(OAc)2 / dimethylformamide / 12 h / 80 °C

With potassium tert-butylate; tetrabutyl-ammonium chloride; tert.-butyl lithium; sodium hydride; potassium carbonate; triphenylphosphine; palladium diacetate; In tetrahydrofuran; diethyl ether; hexane; N,N-dimethyl-formamide; 1.2: Wittig reaction / 4.1: Heck reaction;
DOI:10.1002/chem.200400342

Reference yield:

: 808750-11-0
7-bromo-6-methoxy-2,2-dimethyl-8-vinyl-4H-benzo[1,3]dioxine

: 808750-14-3
(7RS)-7-benzyloxy-6,11-dimethoxy-2,2-dimethyl-12-methylene-7,12-dihydro-4H-1,3-dioxabenzo[a]anthracene

Guidance literature:: Multi-step reaction with 3 steps

1.1: t-BuLi / diethyl ether; hexane / 0.17 h / -78 °C

1.2: diethyl ether; hexane / -78 - 20 °C

2.1: 654 mg / NaH / tetrahydrofuran / 12 h / 40 °C

3.1: 85 percent / n Bu₄NCl; K₂CO₃; PPh₃ / Pd(OAc)2 / dimethylformamide / 12 h / 80 °C

With tetrabutyl-ammonium chloride; tert.-butyl lithium; sodium hydride; potassium carbonate; triphenylphosphine; palladium diacetate; In tetrahydrofuran; diethyl ether; hexane; N,N-dimethyl-formamide; 3.1: Heck reaction;
DOI:10.1002/chem.200400342