1-(2-((2-chloro-5-methylpyrimidin-4-yl)ethynyl)phenyl) cyclopropanecarboxamide

Base Information

Chemical Name:1-(2-((2-chloro-5-methylpyrimidin-4-yl)ethynyl)phenyl) cyclopropanecarboxamide
CAS No.:1566544-04-4
Molecular Formula:C₁₇H₁₄ClN₃O
Molecular Weight:311.771
Hs Code.:

Synonyms:1-(2-((2-chloro-5-methylpyrimidin-4-yl)ethynyl)phenyl) cyclopropanecarboxamide

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Chemical Property of 1-(2-((2-chloro-5-methylpyrimidin-4-yl)ethynyl)phenyl) cyclopropanecarboxamide

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Technology Process of 1-(2-((2-chloro-5-methylpyrimidin-4-yl)ethynyl)phenyl) cyclopropanecarboxamide

There total 1 articles about 1-(2-((2-chloro-5-methylpyrimidin-4-yl)ethynyl)phenyl) cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1780-31-0
2,6-dichloro-5-methylpyrimidine

: 1566543-59-6
1-(2-ethynyl phenyl)cyclopropanecarboxamide

: 1566544-04-4
1-(2-((2-chloro-5-methylpyrimidin-4-yl)ethynyl)phenyl) cyclopropanecarboxamide

Guidance literature:: 2,6-dichloro-5-methylpyrimidine; 1-(2-ethynyl phenyl)cyclopropanecarboxamide; With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In 1,4-dioxane; for 0.166667h; Inert atmosphere;

With triethylamine; In 1,4-dioxane; at 70 ℃; for 1h; Inert atmosphere;

Reference yield: 88.0%

: 1566544-04-4
1-(2-((2-chloro-5-methylpyrimidin-4-yl)ethynyl)phenyl) cyclopropanecarboxamide

: 1566544-05-5
1-(2-(2-(2-chloro-5-methylpyrimidin-4-yl)ethyl)phenyl) cyclopropanecarboxamide

Guidance literature:: With platinum(IV) oxide; hydrogen; In methanol; N,N-dimethyl-formamide; at 20 ℃; for 110h;

Reference yield:

: 1566544-04-4
1-(2-((2-chloro-5-methylpyrimidin-4-yl)ethynyl)phenyl) cyclopropanecarboxamide

: 1566543-23-4
1-(2-(2-(5-methyl-2-((1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen; platinum(IV) oxide / N,N-dimethyl-formamide; methanol / 110 h / 20 °C

2: palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation

3: trifluoroacetic acid / dichloromethane / 20 h / 20 °C

4: sodium tris(acetoxy)borohydride / water; methanol / 4 h / 20 °C / Inert atmosphere

With platinum(IV) oxide; hydrogen; palladium diacetate; sodium tris(acetoxy)borohydride; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;