1-methoxy-4,4-dimethyl-5-nitro-6-[3-p-tolylpyrrol-2-yl]-2-hexanone

Base Information

• Chemical Name: 1-methoxy-4,4-dimethyl-5-nitro-6-[3-p-tolylpyrrol-2-yl]-2-hexanone
• CAS No.: 1345981-17-0
• Molecular Formula: C₂₀H₂₆N₂O₄
• Molecular Weight: 358.437
• Mol file: 1345981-17-0.mol

Synonyms:1-methoxy-4,4-dimethyl-5-nitro-6-[3-p-tolylpyrrol-2-yl]-2-hexanone

Chemical Property of 1-methoxy-4,4-dimethyl-5-nitro-6-[3-p-tolylpyrrol-2-yl]-2-hexanone

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 1-methoxy-4,4-dimethyl-5-nitro-6-[3-p-tolylpyrrol-2-yl]-2-hexanone

There total 1 articles about 1-methoxy-4,4-dimethyl-5-nitro-6-[3-p-tolylpyrrol-2-yl]-2-hexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

3-(4-methylphenyl)-2-(2-nitroethyl)pyrrole (859513-64-7) + 1-methoxy-4-methyl-3-penten-2-one (625857-25-2) → 1-methoxy-4,4-dimethyl-5-nitro-6-[3-p-tolylpyrrol-2-yl]-2-hexanone (1345981-17-0)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; at 20 ℃; for 8h;

DOI:10.1021/jo201967k

Reference yield: 22.0%

1-methoxy-4,4-dimethyl-5-nitro-6-[3-p-tolylpyrrol-2-yl]-2-hexanone (1345981-17-0) → 2,3-dihydro-1-(methoxymethyl)-3,3-dimethyl-7-p-tolyldipyrrin (1345981-23-8)

Guidance literature:

1-methoxy-4,4-dimethyl-5-nitro-6-[3-p-tolylpyrrol-2-yl]-2-hexanone; With sodium methylate; In tetrahydrofuran; methanol; at 0 ℃; for 0.666667h; Inert atmosphere;

With hydrogenchloride; titanium(III) chloride; ammonium acetate; In tetrahydrofuran; methanol; at 20 ℃; Inert atmosphere;

DOI:10.1021/jo201967k

upstream raw materials:

3-(4-methylphenyl)-2-(2-nitroethyl)pyrrole

1-methoxy-4-methyl-3-penten-2-one

Downstream raw materials:

2,3-dihydro-1-(methoxymethyl)-3,3-dimethyl-7-p-tolyldipyrrin