Technology Process of amino-(2,4-difluoro-3-phenoxy-phenyl)-acetonitrile
There total 7 articles about amino-(2,4-difluoro-3-phenoxy-phenyl)-acetonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: cesium fluoride / acetonitrile / Inert atmosphere
2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 80 - 90 °C / Inert atmosphere
3.1: sodium hydrogencarbonate; dimethyl sulfoxide / 80 °C / Inert atmosphere
4.1: lithium hexamethyldisilazane / tetrahydrofuran / -40 - 20 °C
4.2: 20 °C
With
N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hydrogencarbonate; dimethyl sulfoxide; cesium fluoride; lithium hexamethyldisilazane;
In
tetrahydrofuran; tetrachloromethane; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: copper diacetate; pyridine; pyridine N-oxide / dichloromethane / 48 h / 20 °C / Molecular sieve
2.1: lithium hexamethyldisilazane / tetrahydrofuran / -40 - 20 °C
2.2: 20 °C
With
pyridine; pyridine N-oxide; copper diacetate; lithium hexamethyldisilazane;
In
tetrahydrofuran; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydrogencarbonate; dimethyl sulfoxide / 80 °C / Inert atmosphere
2.1: lithium hexamethyldisilazane / tetrahydrofuran / -40 - 20 °C
2.2: 20 °C
With
sodium hydrogencarbonate; dimethyl sulfoxide; lithium hexamethyldisilazane;
In
tetrahydrofuran;
