(R)-N-{1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1H-pyrazol-3-yl}-2-(3-cyano-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionamide

Base Information

Chemical Name:(R)-N-{1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1H-pyrazol-3-yl}-2-(3-cyano-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionamide
CAS No.:1003014-40-1
Molecular Formula:C₂₇H₄₀N₄O₄SSi
Molecular Weight:544.79
Hs Code.:

Synonyms:(R)-N-{1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1H-pyrazol-3-yl}-2-(3-cyano-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionamide

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Chemical Property of (R)-N-{1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1H-pyrazol-3-yl}-2-(3-cyano-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionamide

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Technology Process of (R)-N-{1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1H-pyrazol-3-yl}-2-(3-cyano-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionamide

There total 5 articles about (R)-N-{1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1H-pyrazol-3-yl}-2-(3-cyano-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1003013-09-9
1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1H-pyrazol-3-ylamine

: C₁₆H₁₈ClNO₃S

: 1003014-40-1
(R)-N-{1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1H-pyrazol-3-yl}-2-(3-cyano-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionamide

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 25 ℃; for 2h;

Reference yield:

: 300355-72-0
2-(3-cyano-4-methanesulfonylphenyl)-3-cyclopentylpropionic acid

: 1003014-40-1
(R)-N-{1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1H-pyrazol-3-yl}-2-(3-cyano-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: Resolution of racemate

2: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / 25 °C

3: 2,6-dimethylpyridine / dichloromethane / 2 h / 25 °C

With 2,6-dimethylpyridine; oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane;

Reference yield:

: 1003013-08-8
1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3-nitro-1H-pyrazole

: 1003014-40-1
(R)-N-{1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1H-pyrazol-3-yl}-2-(3-cyano-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / methanol; ethyl acetate / 16 h / 25 °C

2: 2,6-dimethylpyridine / dichloromethane / 2 h / 25 °C

With 2,6-dimethylpyridine; hydrogen; palladium 10% on activated carbon; In methanol; dichloromethane; ethyl acetate;