N⁶-benzoyl-2′-O-[acetal levulinic ester]-5′-O-[4,4′-dimethoxytrityl]-adenosine

Base Information

Chemical Name:N⁶-benzoyl-2′-O-[acetal levulinic ester]-5′-O-[4,4′-dimethoxytrityl]-adenosine
CAS No.:1541908-24-0
Molecular Formula:C₄₄H₄₃N₅O₁₀
Molecular Weight:801.853
Hs Code.:

N<sup>6</sup>-benzoyl-2′-O-[acetal levulinic ester]-5′-O-[4,4′-dimethoxytrityl]-adenosine

Synonyms:N⁶-benzoyl-2′-O-[acetal levulinic ester]-5′-O-[4,4′-dimethoxytrityl]-adenosine

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Chemical Property of N⁶-benzoyl-2′-O-[acetal levulinic ester]-5′-O-[4,4′-dimethoxytrityl]-adenosine

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Technology Process of N⁶-benzoyl-2′-O-[acetal levulinic ester]-5′-O-[4,4′-dimethoxytrityl]-adenosine

There total 4 articles about N⁶-benzoyl-2′-O-[acetal levulinic ester]-5′-O-[4,4′-dimethoxytrityl]-adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 1541908-22-8
N⁶-benzoyl-2′-O-[acetal levulinic ester]-adenosine

: 1541908-24-0
N⁶-benzoyl-2′-O-[acetal levulinic ester]-5′-O-[4,4′-dimethoxytrityl]-adenosine

Guidance literature:: With pyridine; silver nitrate; In tetrahydrofuran; at 20 ℃; for 1.2h; Inert atmosphere;
DOI:10.1021/jo4024182

Reference yield:

: 3128-06-1
5-ketohexanoic acid

: 1541908-24-0
N⁶-benzoyl-2′-O-[acetal levulinic ester]-5′-O-[4,4′-dimethoxytrityl]-adenosine

Guidance literature:: Multi-step reaction with 3 steps

1.1: cesium bicarbonate / N,N-dimethyl-formamide / 3 h / 75 °C

1.2: 3 h / 0 - 20 °C / Inert atmosphere

1.3: 15 h / 20 °C / Inert atmosphere

2.1: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 2.5 h / 20 °C / Inert atmosphere

3.1: silver nitrate; pyridine / tetrahydrofuran / 1.2 h / 20 °C / Inert atmosphere

With pyridine; cesium bicarbonate; silver nitrate; triethylamine tris(hydrogen fluoride); In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo4024182

Reference yield:

: 139434-69-8
N-benzoyl-3′,5′-O-(1,1,3,3-tetraisopropyldisiloxane-1, 3-diyl)-2′-O-[(methylthio)methyl]adenosine

: 1541908-24-0
N⁶-benzoyl-2′-O-[acetal levulinic ester]-5′-O-[4,4′-dimethoxytrityl]-adenosine

Guidance literature:: Multi-step reaction with 3 steps

1.1: cesium bicarbonate / N,N-dimethyl-formamide / 3 h / 75 °C

1.2: 3 h / 0 - 20 °C / Inert atmosphere

1.3: 15 h / 20 °C / Inert atmosphere

2.1: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 2.5 h / 20 °C / Inert atmosphere

3.1: silver nitrate; pyridine / tetrahydrofuran / 1.2 h / 20 °C / Inert atmosphere

With pyridine; cesium bicarbonate; silver nitrate; triethylamine tris(hydrogen fluoride); In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo4024182