6-(2-(hydroxymethyl)-4-methylthiazol-5-yl)-N-(2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide

Base Information

Chemical Name:6-(2-(hydroxymethyl)-4-methylthiazol-5-yl)-N-(2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide
CAS No.:1426668-69-0
Molecular Formula:C₂₃H₂₀N₆O₃S
Molecular Weight:460.516
Hs Code.:

Synonyms:6-(2-(hydroxymethyl)-4-methylthiazol-5-yl)-N-(2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide

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Chemical Property of 6-(2-(hydroxymethyl)-4-methylthiazol-5-yl)-N-(2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide

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Technology Process of 6-(2-(hydroxymethyl)-4-methylthiazol-5-yl)-N-(2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide

There total 5 articles about 6-(2-(hydroxymethyl)-4-methylthiazol-5-yl)-N-(2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1173897-87-4
(5-bromo-4-methyl-1,3-thiazol-2-yl)methanol

: 1426671-46-6
(3-((2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)carbamoyl)imidazo[1,2-a]pyridin-6-yl)boronic acid

: 1426668-69-0
6-(2-(hydroxymethyl)-4-methylthiazol-5-yl)-N-(2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In 1-methyl-pyrrolidin-2-one; at 130 ℃; for 0.333333h; Microwave irradiation;

Reference yield:

: 1426671-16-0
6-bromo-N-(2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide

: 1426668-69-0
6-(2-(hydroxymethyl)-4-methylthiazol-5-yl)-N-(2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; potassium acetate / 1,4-dioxane / 0.33 h / 130 °C / Microwave irradiation

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / 1-methyl-pyrrolidin-2-one / 0.33 h / 130 °C / Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; caesium carbonate; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one;

Reference yield:

: 60710-80-7
5-cyano-2-methylaniline

: 1426668-69-0
6-(2-(hydroxymethyl)-4-methylthiazol-5-yl)-N-(2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydroxylamine / ethanol; water / 70 °C / Reflux

2.1: 1,1'-carbonyldiimidazole / 1-methyl-pyrrolidin-2-one / 0.5 h / 30 °C

2.2: 0.75 h / 30 - 125 °C / Microwave irradiation

3.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate / 65 °C

4.1: bis-triphenylphosphine-palladium(II) chloride; potassium acetate / 1,4-dioxane / 0.33 h / 130 °C / Microwave irradiation

5.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / 1-methyl-pyrrolidin-2-one / 0.33 h / 130 °C / Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; hydroxylamine; potassium acetate; caesium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; 1,1'-carbonyldiimidazole; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol; water; ethyl acetate;