4'-[(5,6-dichloro-1H-benzoimidazol-2-yl)-piperidin-4-ylidene-methyl]-biphenyl-3-carbonitrile

Base Information

Chemical Name:4'-[(5,6-dichloro-1H-benzoimidazol-2-yl)-piperidin-4-ylidene-methyl]-biphenyl-3-carbonitrile
CAS No.:846048-89-3
Molecular Formula:C₂₆H₂₀Cl₂N₄
Molecular Weight:459.378
Hs Code.:

4'-[(5,6-dichloro-1<i>H</i>-benzoimidazol-2-yl)-piperidin-4-ylidene-methyl]-biphenyl-3-carbonitrile

Synonyms:4'-[(5,6-dichloro-1H-benzoimidazol-2-yl)-piperidin-4-ylidene-methyl]-biphenyl-3-carbonitrile

Suppliers and Price of 4'-[(5,6-dichloro-1H-benzoimidazol-2-yl)-piperidin-4-ylidene-methyl]-biphenyl-3-carbonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4'-[(5,6-dichloro-1H-benzoimidazol-2-yl)-piperidin-4-ylidene-methyl]-biphenyl-3-carbonitrile

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4'-[(5,6-dichloro-1H-benzoimidazol-2-yl)-piperidin-4-ylidene-methyl]-biphenyl-3-carbonitrile

There total 8 articles about 4'-[(5,6-dichloro-1H-benzoimidazol-2-yl)-piperidin-4-ylidene-methyl]-biphenyl-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 846049-63-6
2-[(4-bromo-phenyl)-piperidin-4-ylidene-methyl]-5,6-dichloro-1H-benzoimidazole

: 150255-96-2
(3‐cyanophenyl)boronic acid

: 846048-89-3
4'-[(5,6-dichloro-1H-benzoimidazol-2-yl)-piperidin-4-ylidene-methyl]-biphenyl-3-carbonitrile

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In methanol; toluene;
DOI:10.1016/j.bmcl.2006.04.062

Reference yield:

: 5,6-dichloro-2-(2-trimethylsilanyl-ethoxymethyl)-1H-benzoimidazole

: 846048-89-3
4'-[(5,6-dichloro-1H-benzoimidazol-2-yl)-piperidin-4-ylidene-methyl]-biphenyl-3-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / n-BuLi / tetrahydrofuran

2: 94 percent / SOCl₂; pyridine

3: 43 percent / pyridine / 150 °C

4: 100 percent / TFA / CH₂Cl₂ / 20 °C

5: 58 percent / Pd(PPh₃)4; aq. Na₂CO₃ / toluene; methanol

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; thionyl chloride; sodium carbonate; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1016/j.bmcl.2006.04.062

Reference yield:

: 4-[(4-bromo-phenyl)-chloro-(5,6-dichloro-1H-benzoimidazol-2-yl)-methyl]-piperidine-1-carboxylic acid tert-butyl ester

: 846048-89-3
4'-[(5,6-dichloro-1H-benzoimidazol-2-yl)-piperidin-4-ylidene-methyl]-biphenyl-3-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 43 percent / pyridine / 150 °C

2: 100 percent / TFA / CH₂Cl₂ / 20 °C

3: 58 percent / Pd(PPh₃)4; aq. Na₂CO₃ / toluene; methanol

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; trifluoroacetic acid; In methanol; dichloromethane; toluene;
DOI:10.1016/j.bmcl.2006.04.062