AMG-076 free base

Base Information

Chemical Name:AMG-076 free base
CAS No.:693823-79-9
Molecular Formula:C₂₆H₃₃F₃N₂O₂
Molecular Weight:462.555
Hs Code.:
UNII:HX4T7JEV3D
DSSTox Substance ID:DTXSID70219485
Nikkaji Number:J2.551.466A
Wikidata:Q27280138
Pharos Ligand ID:JNFA59L2XQ4N
ChEMBL ID:CHEMBL2032049

Synonyms:AMG-076 free base;UNII-HX4T7JEV3D;HX4T7JEV3D;693823-79-9;CHEMBL2032049;Cyclohexanecarboxylic acid, 1-(2-((4aR,11R,11aS)-1,3,4,4a,5,6,11,11a-octahydro-11-methyl-9-(trifluoromethyl)-2H-pyrido(4,3-b)carbazol-2-yl)ethyl)-;D0X4MC;SCHEMBL2742722;DTXSID70219485;WAOZNBXSEVIAGX-MBOZVWFJSA-N;BDBM50383522;Q27280138;(4aR)-2-[2-(1-Carboxycyclohexyl)ethyl]-2,3,4,4abeta,5,6,11,11aalpha-octahydro-9-(trifluoromethyl)-11alpha-methyl-1H-pyrido[4,3-b]carbazole;1-(2-((4aR,11R,11aS)-11-methyl-9-(trifluoromethyl)-3,4,4a,5,11,11a-hexahydro-1H-pyrido[4,3-b]carbazol-2(6H)-yl)ethyl)cyclohexanecarboxylic acid;1-[2-[(4aR,11R,11aS)-11-methyl-9-(trifluoromethyl)-1,3,4,4a,5,6,11,11a-octahydropyrido[4,3-b]carbazol-2-yl]ethyl]cyclohexane-1-carboxylic acid

Suppliers and Price of AMG-076 free base

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
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Total 0 raw suppliers

Chemical Property of AMG-076 free base

Chemical Property:

XLogP3:3.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:462.24941279
Heavy Atom Count:33
Complexity:723

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1C2CN(CCC2CC3=C1C4=C(N3)C=CC(=C4)C(F)(F)F)CCC5(CCCCC5)C(=O)O
Isomeric SMILES:C[C@@H]1[C@H]2CN(CC[C@@H]2CC3=C1C4=C(N3)C=CC(=C4)C(F)(F)F)CCC5(CCCCC5)C(=O)O

Technology Process of AMG-076 free base

There total 6 articles about AMG-076 free base which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 693823-71-1
(4aR,11R,11aS)-11-methyl-9-(trifluoromethyl)-2,3,4,4a,5,6,11,11a-octahydro-1H-pyrido[4,3-b]carbazole

: (+/-)-3-hydroxy-2-oxa-spiro[4.5]decan-1-one

: 693823-79-9
1-[2-((4aR,11R,11aS)-11-methyl-9-trifluoromethyl-2,3,4,4a,5,6,11,11a-octahydropyrido[4,3-b]carbazol-2-yl)ethyl]cyclohexanecarboxylic acid

Guidance literature:: With hydrogen; acetic acid; platinum on activated charcoal; In isopropyl alcohol; at 40 ℃; for 24h; under 1034.32 Torr;
DOI:10.1021/jo701894v

Reference yield:

: C₉H₁₄O₃

: 693823-79-9
1-[2-((4aR,11R,11aS)-11-methyl-9-trifluoromethyl-2,3,4,4a,5,6,11,11a-octahydropyrido[4,3-b]carbazol-2-yl)ethyl]cyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride

2: sodium tris(acetoxy)borohydride / dichloromethane

With hydrogenchloride; sodium tris(acetoxy)borohydride; In dichloromethane;
DOI:10.1016/j.bmcl.2012.04.006

Reference yield:

: 41487-76-7
methyl 1-(2-oxoethyl)cyclohexane-1-carboxylate

: 693823-79-9
1-[2-((4aR,11R,11aS)-11-methyl-9-trifluoromethyl-2,3,4,4a,5,6,11,11a-octahydropyrido[4,3-b]carbazol-2-yl)ethyl]cyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: water; lithium hydroxide / tetrahydrofuran

2: hydrogenchloride

3: sodium tris(acetoxy)borohydride / dichloromethane

With hydrogenchloride; water; sodium tris(acetoxy)borohydride; lithium hydroxide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2012.04.006