2-((5-((4-fluorophenyl)(pyridin-2-ylmethyl)carbamoyl)pyridin-2-ylthio)methyl)phenylboronic acid

Base Information

Chemical Name:2-((5-((4-fluorophenyl)(pyridin-2-ylmethyl)carbamoyl)pyridin-2-ylthio)methyl)phenylboronic acid
CAS No.:1240495-68-4
Molecular Formula:C₂₅H₂₁BFN₃O₃S
Molecular Weight:473.335
Hs Code.:

Synonyms:2-((5-((4-fluorophenyl)(pyridin-2-ylmethyl)carbamoyl)pyridin-2-ylthio)methyl)phenylboronic acid

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Chemical Property of 2-((5-((4-fluorophenyl)(pyridin-2-ylmethyl)carbamoyl)pyridin-2-ylthio)methyl)phenylboronic acid

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Technology Process of 2-((5-((4-fluorophenyl)(pyridin-2-ylmethyl)carbamoyl)pyridin-2-ylthio)methyl)phenylboronic acid

There total 6 articles about 2-((5-((4-fluorophenyl)(pyridin-2-ylmethyl)carbamoyl)pyridin-2-ylthio)methyl)phenylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1240495-96-8
N-(4-fluorophenyl)-6-mercapto-N-(pyridin-2-ylmethyl)nicotinamide

: 91983-14-1
2-bromomethylphenylboronic acid

: 1240495-68-4
2-((5-((4-fluorophenyl)(pyridin-2-ylmethyl)carbamoyl)pyridin-2-ylthio)methyl)phenylboronic acid

Guidance literature:: With sodium hydroxide; In ethanol; water; for 1h; Reflux;

Reference yield:

: 364078-28-4
N-(4-fluoro-phenyl)-6-chloro-nicotinamide

: 1240495-68-4
2-((5-((4-fluorophenyl)(pyridin-2-ylmethyl)carbamoyl)pyridin-2-ylthio)methyl)phenylboronic acid

Guidance literature:: Multi-step reaction with 3 steps

1: tetra(n-butyl)ammonium hydroxide; sodium hydroxide / toluene; water / 20 °C

2: sodium hydrogen sulfide / N,N-dimethyl-formamide / 2 h / Reflux

3: sodium hydroxide / ethanol; water / 2 h / Reflux

With sodium hydrogen sulfide; tetra(n-butyl)ammonium hydroxide; sodium hydroxide; In ethanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm500827t

Reference yield:

: 1240495-95-7
6-chloro-N-(4-fluorophenyl)-N-(pyridin-2-ylmethyl)nicotinamide

: 1240495-68-4
2-((5-((4-fluorophenyl)(pyridin-2-ylmethyl)carbamoyl)pyridin-2-ylthio)methyl)phenylboronic acid

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogen sulfide / N,N-dimethyl-formamide / 2 h / Reflux

2: sodium hydroxide / ethanol; water / 2 h / Reflux

With sodium hydrogen sulfide; sodium hydroxide; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm500827t