9-[(R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-fluoro-2,5-dihydro-furan-2-yl]-9H-purin-6-ylamine

Base Information

Chemical Name:9-[(R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-fluoro-2,5-dihydro-furan-2-yl]-9H-purin-6-ylamine
CAS No.:212954-59-1
Molecular Formula:C₂₆H₂₈FN₅O₂Si
Molecular Weight:489.625
Hs Code.:

Synonyms:9-[(R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-fluoro-2,5-dihydro-furan-2-yl]-9H-purin-6-ylamine

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Chemical Property of 9-[(R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-fluoro-2,5-dihydro-furan-2-yl]-9H-purin-6-ylamine

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Technology Process of 9-[(R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-fluoro-2,5-dihydro-furan-2-yl]-9H-purin-6-ylamine

There total 7 articles about 9-[(R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-fluoro-2,5-dihydro-furan-2-yl]-9H-purin-6-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 17995-04-9
N,N-bis(trimethysilyl)adenine

: 212954-55-7
Benzoic acid (R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-3-fluoro-2,5-dihydro-furan-2-yl ester

: 212954-59-1
9-[(R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-fluoro-2,5-dihydro-furan-2-yl]-9H-purin-6-ylamine

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; Ambient temperature;
DOI:10.1016/S0960-894X(98)00277-7

Reference yield:

: 128075-94-5
(R)-5-{[(tert-butyldiphenylsilyl)oxy]methyl}dihydrofuran-2(3H)-one

: 212954-59-1
9-[(R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-fluoro-2,5-dihydro-furan-2-yl]-9H-purin-6-ylamine

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) LiHMDS / 1.) THF, -78 deg C, 2.) THF

2: 1.) LiHMDS, 2.) FN(SO₂)Ph)2 / 1.) THF, -78 deg C, 2.) THF

3: 90 percent / 39percent H₂O₂, pyridine / Ambient temperature

4: 93 percent / DIBAL-H / toluene / -78 °C

5: 87 percent / pyridine

6: 70 percent / TMSOTf / CH₂Cl₂ / Ambient temperature

With pyridine; trimethylsilyl trifluoromethanesulfonate; dihydrogen peroxide; diisobutylaluminium hydride; lithium hexamethyldisilazane; In dichloromethane; toluene;
DOI:10.1016/S0960-894X(98)00277-7

Reference yield:

: 189818-62-0
5-O-(tert-butyldiphenylsilyl)-3-deoxy-2-Se-phenyl-2-seleno-L-erythro-pentonic acid-γ-lactone

: 212954-59-1
9-[(R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-fluoro-2,5-dihydro-furan-2-yl]-9H-purin-6-ylamine

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) LiHMDS, 2.) FN(SO₂)Ph)2 / 1.) THF, -78 deg C, 2.) THF

2: 90 percent / 39percent H₂O₂, pyridine / Ambient temperature

3: 93 percent / DIBAL-H / toluene / -78 °C

4: 87 percent / pyridine

5: 70 percent / TMSOTf / CH₂Cl₂ / Ambient temperature

With pyridine; trimethylsilyl trifluoromethanesulfonate; dihydrogen peroxide; diisobutylaluminium hydride; lithium hexamethyldisilazane; In dichloromethane; toluene;
DOI:10.1016/S0960-894X(98)00277-7