(S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-4-ureido-butyric acid

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Chemical Name:(S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-4-ureido-butyric acid
CAS No.:96846-10-5
Molecular Formula:C₂₀H₂₄N₁₀O₄
Molecular Weight:468.475
Hs Code.:

Synonyms:(S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-4-ureido-butyric acid

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Chemical Property of (S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-4-ureido-butyric acid

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Technology Process of (S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-4-ureido-butyric acid

There total 4 articles about (S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-4-ureido-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 52853-40-4
6-bromomethyl-2,4-diaminopteridine hydrobromide

: 96846-07-0
(S)-2-(4-Methylamino-benzoylamino)-4-ureido-butyric acid

: 96846-10-5
(S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-4-ureido-butyric acid

Guidance literature:: In N,N-dimethyl acetamide; at 20 - 25 ℃; for 120h;
DOI:10.1021/jm00146a008

Reference yield:

: 1190-47-2
L-2-amino-4-ureidobutyrate

: 96846-10-5
(S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-4-ureido-butyric acid

Guidance literature:: Multi-step reaction with 3 steps

1: 74 percent / (i-Pr)2NEt / dioxane; H₂O

2: H₂ / 30percent Pd/C / acetic acid / 3.5 h / 25 °C / 2324.2 Torr

3: 49 percent / N,N-dimethyl-acetamide / 120 h / 20 - 25 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1,4-dioxane; N,N-dimethyl acetamide; water; acetic acid;
DOI:10.1021/jm00146a008

Reference yield:

: 96846-00-3
γ-Ureido-L-α-tosylamino-buttersaeure

: 96846-10-5
(S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-4-ureido-butyric acid

Guidance literature:: Multi-step reaction with 4 steps

1: 67 percent / 30percent HBr, CH₃COOH, phenol / 96 h

2: 74 percent / (i-Pr)2NEt / dioxane; H₂O

3: H₂ / 30percent Pd/C / acetic acid / 3.5 h / 25 °C / 2324.2 Torr

4: 49 percent / N,N-dimethyl-acetamide / 120 h / 20 - 25 °C

With hydrogen bromide; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; phenol; palladium on activated charcoal; In 1,4-dioxane; N,N-dimethyl acetamide; water; acetic acid;
DOI:10.1021/jm00146a008