7-(3-(piperidin-1-yl)propoxy)-1-(4-fluorobenzyl)-3,4-dihydro-2(1H)quinolinone

Base Information

Chemical Name:7-(3-(piperidin-1-yl)propoxy)-1-(4-fluorobenzyl)-3,4-dihydro-2(1H)quinolinone
CAS No.:1609210-34-5
Molecular Formula:C₂₄H₂₉FN₂O₂
Molecular Weight:396.505
Hs Code.:

Synonyms:7-(3-(piperidin-1-yl)propoxy)-1-(4-fluorobenzyl)-3,4-dihydro-2(1H)quinolinone

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Chemical Property of 7-(3-(piperidin-1-yl)propoxy)-1-(4-fluorobenzyl)-3,4-dihydro-2(1H)quinolinone

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Technology Process of 7-(3-(piperidin-1-yl)propoxy)-1-(4-fluorobenzyl)-3,4-dihydro-2(1H)quinolinone

There total 3 articles about 7-(3-(piperidin-1-yl)propoxy)-1-(4-fluorobenzyl)-3,4-dihydro-2(1H)quinolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 58033-07-1
7-(3-(piperidin-1-yl)propoxy)-3,4-dihydroquinolin-2(1H)-one

: 459-46-1
4-Fluorobenzyl bromide

: 1609210-34-5
7-(3-(piperidin-1-yl)propoxy)-1-(4-fluorobenzyl)-3,4-dihydro-2(1H)quinolinone

Guidance literature:: 7-(3-(piperidin-1-yl)propoxy)-3,4-dihydroquinolin-2(1H)-one; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.5h; Inert atmosphere;

4-Fluorobenzyl bromide; In N,N-dimethyl-formamide; mineral oil; at 50 ℃; for 3h;
DOI:10.1016/j.ejmech.2014.04.019

Reference yield:

: 7-hydroxy-3,4-dihydroxy-2(1H)quinolinone

: 1609210-34-5
7-(3-(piperidin-1-yl)propoxy)-1-(4-fluorobenzyl)-3,4-dihydro-2(1H)quinolinone

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetone / Reflux

2.1: potassium carbonate; potassium iodide / acetonitrile / Reflux

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

3.2: 3 h / 50 °C

With sodium hydride; potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; acetone; acetonitrile; mineral oil;
DOI:10.1016/j.ejmech.2014.04.019

Reference yield:

: 82657-32-7
7-(3-bromopropoxy)-3,4-dihydroquinolin-2(1H)-one

: 1609210-34-5
7-(3-(piperidin-1-yl)propoxy)-1-(4-fluorobenzyl)-3,4-dihydro-2(1H)quinolinone

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate; potassium iodide / acetonitrile / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

2.2: 3 h / 50 °C

With sodium hydride; potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.1016/j.ejmech.2014.04.019