Technology Process of (3R,3aR,5R,6R,7S,7aS)-6,7-Bis-benzyloxy-5-benzyloxymethyl-3-methyl-hexahydro-furo[3,2-b]pyran-2-one
There total 5 articles about (3R,3aR,5R,6R,7S,7aS)-6,7-Bis-benzyloxy-5-benzyloxymethyl-3-methyl-hexahydro-furo[3,2-b]pyran-2-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 50 percent / TsOH, pyridine / tetrahydrofuran / 1 h / Heating
2: 1) nBu3SnH, AIBN; 2) m-chloroperoxybenzoic acid, BF3*Et2O / 1) benzene, reflux, 24 h; 2) CH2Cl2, room temp., 17 h
With
pyridine; 2,2'-azobis(isobutyronitrile); boron trifluoride diethyl etherate; tri-n-butyl-tin hydride; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran;
DOI:10.1016/S0040-4039(01)93880-8
- Guidance literature:
-
Multi-step reaction with 3 steps
1: MeONa / methanol / Ambient temperature
2: 50 percent / TsOH, pyridine / tetrahydrofuran / 1 h / Heating
3: 1) nBu3SnH, AIBN; 2) m-chloroperoxybenzoic acid, BF3*Et2O / 1) benzene, reflux, 24 h; 2) CH2Cl2, room temp., 17 h
With
pyridine; 2,2'-azobis(isobutyronitrile); boron trifluoride diethyl etherate; tri-n-butyl-tin hydride; sodium methylate; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; methanol;
DOI:10.1016/S0040-4039(01)93880-8
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 65 percent / n-BuLi / tetrahydrofuran / 24 h / from -78 deg C to room temperature
2: 1) nBu3SnH, AIBN; 2) m-chloroperoxybenzoic acid, BF3*Et2O / 1) benzene, reflux, 24 h; 2) CH2Cl2, room temp., 17 h
With
n-butyllithium; 2,2'-azobis(isobutyronitrile); boron trifluoride diethyl etherate; tri-n-butyl-tin hydride; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran;
DOI:10.1016/S0040-4039(01)93880-8
