(S)-1-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)-3-(2-fluoro-5-methyl-4-(methylsulfonyl)phenoxy)pyrrolidin-2-one

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Chemical Name:(S)-1-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)-3-(2-fluoro-5-methyl-4-(methylsulfonyl)phenoxy)pyrrolidin-2-one
CAS No.:1351167-10-6
Molecular Formula:C₂₃H₂₉FN₄O₄S
Molecular Weight:476.572
Hs Code.:

Synonyms:(S)-1-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)-3-(2-fluoro-5-methyl-4-(methylsulfonyl)phenoxy)pyrrolidin-2-one

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Chemical Property of (S)-1-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)-3-(2-fluoro-5-methyl-4-(methylsulfonyl)phenoxy)pyrrolidin-2-one

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Technology Process of (S)-1-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)-3-(2-fluoro-5-methyl-4-(methylsulfonyl)phenoxy)pyrrolidin-2-one

There total 7 articles about (S)-1-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)-3-(2-fluoro-5-methyl-4-(methylsulfonyl)phenoxy)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1351167-11-7
(S)-3-(4-bromo-2-fluoro-5-methylphenoxy)-1-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)pyrrolidin-2-one

: 20277-69-4
sodium methansulfinate

: 1351167-10-6
(S)-1-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)-3-(2-fluoro-5-methyl-4-(methylsulfonyl)phenoxy)pyrrolidin-2-one

Guidance literature:: copper(I) triflate benzene complex; trans-1,2-cyclohexanediamine; In dimethyl sulfoxide; at 110 ℃; Inert atmosphere;

Reference yield:

: 550400-07-2
4-bromo-2-fluoro-5-methylphenol

: 1351167-10-6
(S)-1-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)-3-(2-fluoro-5-methyl-4-(methylsulfonyl)phenoxy)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: tributylphosphine; di-tert-butyl-diazodicarboxylate / toluene / 0 - 20 °C / Inert atmosphere

2.1: trimethylaluminum / dichloromethane / 0.25 h

2.2: 1 h / 20 °C

3.1: triphenylphosphine; di-tert-butyl-diazodicarboxylate / toluene / 0 - 20 °C

4.1: hydrogenchloride / dichloromethane; 1,4-dioxane; methanol / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 110 °C

6.1: trans-1,2-cyclohexanediamine; copper(I) triflate benzene complex / dimethyl sulfoxide / 110 °C / Inert atmosphere

With hydrogenchloride; tributylphosphine; di-tert-butyl-diazodicarboxylate; trimethylaluminum; N-ethyl-N,N-diisopropylamine; triphenylphosphine; copper(I) triflate benzene complex; trans-1,2-cyclohexanediamine; In 1,4-dioxane; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 63762-79-8
2-fluoro-5-methylphenol

: 1351167-10-6
(S)-1-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)-3-(2-fluoro-5-methyl-4-(methylsulfonyl)phenoxy)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetra-N-butylammonium tribromide / chloroform / 0.5 h / 20 °C

2.1: tributylphosphine; di-tert-butyl-diazodicarboxylate / toluene / 0 - 20 °C / Inert atmosphere

3.1: trimethylaluminum / dichloromethane / 0.25 h

3.2: 1 h / 20 °C

4.1: triphenylphosphine; di-tert-butyl-diazodicarboxylate / toluene / 0 - 20 °C

5.1: hydrogenchloride / dichloromethane; 1,4-dioxane; methanol / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 110 °C

7.1: trans-1,2-cyclohexanediamine; copper(I) triflate benzene complex / dimethyl sulfoxide / 110 °C / Inert atmosphere

With hydrogenchloride; tributylphosphine; di-tert-butyl-diazodicarboxylate; trimethylaluminum; tetra-N-butylammonium tribromide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; copper(I) triflate benzene complex; trans-1,2-cyclohexanediamine; In 1,4-dioxane; methanol; dichloromethane; chloroform; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;