4-[(S)-2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridine-3-carbaldehyde

Base Information

• Chemical Name: 4-[(S)-2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridine-3-carbaldehyde
• CAS No.: 1008452-02-5
• Molecular Formula: C₁₄H₁₃ClN₂O₃
• Molecular Weight: 292.722

Synonyms:4-[(S)-2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridine-3-carbaldehyde

Chemical Property of 4-[(S)-2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridine-3-carbaldehyde

Chemical Property:

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Technology Process of 4-[(S)-2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridine-3-carbaldehyde

There total 1 articles about 4-[(S)-2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridine-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

(S)-1-(3-chloro-phenyl)-2-(3-[1,3]dioxolan-2-yl-2-methoxy-pyridin-4-ylamino)-ethanol (936939-80-9) → 4-[(S)-2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridine-3-carbaldehyde (1008452-02-5)

Guidance literature:

With hydrogenchloride; water; In 1,4-dioxane; at 70 ℃; for 4h;

Reference yield: 0.4%

4-[(S)-2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridine-3-carbaldehyde (1008452-02-5) + 5-(1,1-difluoro-2-morpholin-4-yl-ethyl)-3-methyl-benzene-1,2-diamine (936939-81-0) → 4-[(S)-2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-3-[6-(1,1-difluoro-2-morpholin-4-yl-ethyl)-4-methyl-1H-benzoimidazol-2-yl]-1H-pyridin-2-one trifluoroacetate

Guidance literature:

With acetic acid; In ethanol; at 40 ℃; for 72h;

Reference yield:

4-[(S)-2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridine-3-carbaldehyde (1008452-02-5) + C16H26N4 → 4-[(S)-2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-3-[6-(2,8-diaza-spiro[5.5]undec-2-yl)-4-methyl-1H-benzoimidazol-2-yl]-1H-pyridin-2-one (936935-54-5)

Guidance literature:

In N,N-dimethyl acetamide; at 95 ℃; for 3h; Product distribution / selectivity;

upstream raw materials:

(S)-1-(3-chloro-phenyl)-2-(3-[1,3]dioxolan-2-yl-2-methoxy-pyridin-4-ylamino)-ethanol

Downstream raw materials:

4-[(S)-2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-3-[6-(2,8-diaza-spiro[5.5]undec-2-yl)-4-methyl-1H-benzoimidazol-2-yl]-1H-pyridin-2-one

3-[6-(8-benzyl-2,8-diaza-spiro[5.5]undec-2-yl)-4-methyl-1H-benzoimidazol-2-yl]-4-[(S)-2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-1H-pyridin-2-one

4-[(S)-2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-3-[6-(7-ethyl-2,7-diaza-spiro[4.4]non-2-yl)-4-methyl-1H-benzoimidazol-2-yl]-1H-pyridin-2-one

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