2-chloro-N-{5-[4-ethyl-6-(2-methyl-pyridin-4-yl)-pyrimidin-5-ylethynyl]-2-methyl-pyridin-3-yl}-benzenesulfonamide

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Chemical Name:2-chloro-N-{5-[4-ethyl-6-(2-methyl-pyridin-4-yl)-pyrimidin-5-ylethynyl]-2-methyl-pyridin-3-yl}-benzenesulfonamide
CAS No.:1392099-65-8
Molecular Formula:C₂₆H₂₂ClN₅O₂S
Molecular Weight:504.012
Hs Code.:

Synonyms:2-chloro-N-{5-[4-ethyl-6-(2-methyl-pyridin-4-yl)-pyrimidin-5-ylethynyl]-2-methyl-pyridin-3-yl}-benzenesulfonamide

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Chemical Property of 2-chloro-N-{5-[4-ethyl-6-(2-methyl-pyridin-4-yl)-pyrimidin-5-ylethynyl]-2-methyl-pyridin-3-yl}-benzenesulfonamide

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Technology Process of 2-chloro-N-{5-[4-ethyl-6-(2-methyl-pyridin-4-yl)-pyrimidin-5-ylethynyl]-2-methyl-pyridin-3-yl}-benzenesulfonamide

There total 13 articles about 2-chloro-N-{5-[4-ethyl-6-(2-methyl-pyridin-4-yl)-pyrimidin-5-ylethynyl]-2-methyl-pyridin-3-yl}-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 1392100-79-6
5-[4-ethyl-6-(2-methyl-pyridin-4-yl)-pyrimidin-5-ylethynyl]-2-methyl-pyridin-3-ylamine

: 2905-23-9
2-chlorophenylsulfonyl chloride

: 1392099-65-8
2-chloro-N-{5-[4-ethyl-6-(2-methyl-pyridin-4-yl)-pyrimidin-5-ylethynyl]-2-methyl-pyridin-3-yl}-benzenesulfonamide

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

: 67443-38-3
5-bromo-2-chloro-3-nitropyridine

: 1392099-65-8
2-chloro-N-{5-[4-ethyl-6-(2-methyl-pyridin-4-yl)-pyrimidin-5-ylethynyl]-2-methyl-pyridin-3-yl}-benzenesulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

1.2: 2 h / 0 - 50 °C

2.1: hydrogenchloride / water / 3 h / Reflux

3.1: ammonium chloride; iron / ethanol / 3 h / Reflux

4.1: diisopropylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 100 °C / Inert atmosphere

5.1: potassium carbonate; methanol / 3 h / 20 °C

6.1: diisopropylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / dimethyl sulfoxide / 65 °C / Inert atmosphere

7.1: sodium carbonate / [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) / 1-methyl-pyrrolidin-2-one; water / 0.25 h / 120 °C / microwave irradiation

8.1: pyridine / dichloromethane / 4 h / 20 °C

With pyridine; hydrogenchloride; methanol; iron; sodium hydride; sodium carbonate; potassium carbonate; ammonium chloride; diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 911434-05-4
5-bromo-2-methyl-3-nitropyridine

: 1392099-65-8
2-chloro-N-{5-[4-ethyl-6-(2-methyl-pyridin-4-yl)-pyrimidin-5-ylethynyl]-2-methyl-pyridin-3-yl}-benzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: ammonium chloride; iron / ethanol / 3 h / Reflux

2: diisopropylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 100 °C / Inert atmosphere

3: potassium carbonate; methanol / 3 h / 20 °C

4: diisopropylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / dimethyl sulfoxide / 65 °C / Inert atmosphere

5: sodium carbonate / [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) / 1-methyl-pyrrolidin-2-one; water / 0.25 h / 120 °C / microwave irradiation

6: pyridine / dichloromethane / 4 h / 20 °C

With pyridine; methanol; iron; sodium carbonate; potassium carbonate; ammonium chloride; diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); In 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; water; dimethyl sulfoxide;