(S)-1-(1-(benzyloxy)-3-(o-nitrophenylsulfonamido)propan-2-yl)naphthalen-2-yl trifluoromethanesulfonate

Base Information

Chemical Name:(S)-1-(1-(benzyloxy)-3-(o-nitrophenylsulfonamido)propan-2-yl)naphthalen-2-yl trifluoromethanesulfonate
CAS No.:1350980-19-6
Molecular Formula:C₂₇H₂₃F₃N₂O₈S₂
Molecular Weight:624.615
Hs Code.:

Synonyms:(S)-1-(1-(benzyloxy)-3-(o-nitrophenylsulfonamido)propan-2-yl)naphthalen-2-yl trifluoromethanesulfonate

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Chemical Property of (S)-1-(1-(benzyloxy)-3-(o-nitrophenylsulfonamido)propan-2-yl)naphthalen-2-yl trifluoromethanesulfonate

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Technology Process of (S)-1-(1-(benzyloxy)-3-(o-nitrophenylsulfonamido)propan-2-yl)naphthalen-2-yl trifluoromethanesulfonate

There total 8 articles about (S)-1-(1-(benzyloxy)-3-(o-nitrophenylsulfonamido)propan-2-yl)naphthalen-2-yl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 1350980-18-5
(S)-N-(3-(benzyloxy)-2-(2-hydroxynaphthalen-1-yl)propyl)-o-nitrobenzenesulfonamide

: 1350980-19-6
(S)-1-(1-(benzyloxy)-3-(o-nitrophenylsulfonamido)propan-2-yl)naphthalen-2-yl trifluoromethanesulfonate

Guidance literature:: With pyridine; at 10 - 20 ℃;
DOI:10.1016/j.tetlet.2011.10.105

Reference yield:

: 100-44-7
benzyl chloride

: 1350980-19-6
(S)-1-(1-(benzyloxy)-3-(o-nitrophenylsulfonamido)propan-2-yl)naphthalen-2-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hydroxide

1.2: 10 - 60 °C

2.1: ammonium cerium (IV) nitrate; sodium nitrite / acetonitrile / 0 - 20 °C

3.1: C₂₈H₂₈F₆N₄S / toluene / 96 h / -50 °C / Molecular sieve

4.1: ammonium chloride; zinc / ethanol; water / 72 h / 20 °C

5.1: pyridine / 40 - 60 °C

6.1: pyridine / 10 - 20 °C

With pyridine; ammonium cerium (IV) nitrate; C₂₈H₂₈F₆N₄S; ammonium chloride; potassium hydroxide; zinc; sodium nitrite; In ethanol; water; toluene; acetonitrile; 3.1: Friedel Crafts alkylation;
DOI:10.1016/j.tetlet.2011.10.105

Reference yield:

: 1350980-13-0
(S)-1-(1-(benzyloxy)-3-nitropropan-2-yl)naphthalen-2-ol

: 1350980-19-6
(S)-1-(1-(benzyloxy)-3-(o-nitrophenylsulfonamido)propan-2-yl)naphthalen-2-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium chloride; zinc / ethanol; water / 72 h / 20 °C

2: pyridine / 40 - 60 °C

3: pyridine / 10 - 20 °C

With pyridine; ammonium chloride; zinc; In ethanol; water;
DOI:10.1016/j.tetlet.2011.10.105