(E)-diethyl 2-methyl-1-(2-methyl-3-phenylallyloxy)prop-1-enylphosphonate

Base Information

• Chemical Name: (E)-diethyl 2-methyl-1-(2-methyl-3-phenylallyloxy)prop-1-enylphosphonate
• CAS No.: 1401467-15-9
• Molecular Formula: C₁₈H₂₇O₄P
• Molecular Weight: 338.384
• Mol file: 1401467-15-9.mol

Synonyms:(E)-diethyl 2-methyl-1-(2-methyl-3-phenylallyloxy)prop-1-enylphosphonate

Chemical Property of (E)-diethyl 2-methyl-1-(2-methyl-3-phenylallyloxy)prop-1-enylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of (E)-diethyl 2-methyl-1-(2-methyl-3-phenylallyloxy)prop-1-enylphosphonate

There total 1 articles about (E)-diethyl 2-methyl-1-(2-methyl-3-phenylallyloxy)prop-1-enylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethyl isobutyryl phosphonate (1523-69-9) + (E)-1-(3-bromo-2-methylprop-1-en-1-yl)benzene (83126-01-6) → (E)-diethyl 2-methyl-1-(2-methyl-3-phenylallyloxy)prop-1-enylphosphonate (1401467-15-9)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 0 ℃;

DOI:10.1002/anie.201203092

Reference yield: 96.0%

(E)-diethyl 2-methyl-1-(2-methyl-3-phenylallyloxy)prop-1-enylphosphonate (1401467-15-9) → (R)-diethyl 2,2,4-trimethyl-3-phenylpent-4-enoylphosphonate (1401466-92-9)

Guidance literature:

With copper(II) bis(trifluoromethanesulfonate); (4R,4'R)-2,2'-(propane-2,2'diyl)bis(4-phenyl-4,5-dihydrooxazole); In hexane; dichloromethane; at 20 ℃; for 4h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1002/anie.201203092

upstream raw materials:

diethyl isobutyryl phosphonate

(E)-1-(3-bromo-2-methylprop-1-en-1-yl)benzene

Downstream raw materials:

(R)-diethyl 2,2,4-trimethyl-3-phenylpent-4-enoylphosphonate

Refernces