Clofurac

Base Information

Chemical Name:Clofurac
CAS No.:60986-89-2
Molecular Formula:C14H15 Cl O2
Molecular Weight:250.72
Hs Code.:2932209090
UNII:0V7WAB3NV4
DSSTox Substance ID:DTXSID10866836
Nikkaji Number:J18.080G
Wikidata:Q27231144
NCI Thesaurus Code:C77347
ChEMBL ID:CHEMBL33958
Mol file:60986-89-2.mol

Synonyms:5-CCHDHBF;5-chloro-6-cyclohexyl-2,3-dihydrobenzofuran-2-one

Suppliers and Price of Clofurac

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
CLOFURAC 95.00%
5MG
$ 499.21

Total 1 raw suppliers

Chemical Property of Clofurac

Chemical Property:

Vapor Pressure:6.47E-06mmHg at 25°C
Boiling Point:378°C at 760 mmHg
Flash Point:197.2°C
PSA：26.30000
Density:1.258g/cm³
LogP:3.84920
XLogP3:4.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:250.0760574
Heavy Atom Count:17
Complexity:299

Purity/Quality:

99% ^*data from raw suppliers

CLOFURAC 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCC(CC1)C2=C(C=C3CC(=O)OC3=C2)Cl

Technology Process of Clofurac

There total 6 articles about Clofurac which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 60987-05-5
2-(5-chloro-4-cyclohexyl-2-hydroxyphenyl)-acetic acid

: 60986-89-2
5-chloro-6-cyclohexyl-2,3-dihydrobenzofuran-2-one

Guidance literature:: With toluene-4-sulfonic acid; In toluene; for 3h; Heating;
DOI:10.1021/jm00144a019

Reference yield:

: 41876-58-8
1-cyclohexyl-3-methoxybenzene

: 60986-89-2
5-chloro-6-cyclohexyl-2,3-dihydrobenzofuran-2-one

Guidance literature:: Multi-step reaction with 8 steps

1: 69 percent / SnCl₄ / CH₂Cl₂ / 20 h / Ambient temperature

2: 91 percent / S / 6 h / Heating

3: 75 percent / KOH, H₂O / ethanol / 20 h / Heating

4: HCl(g) / 0.5 h

5: SOCl₂ / CH₂Cl₂ / Ambient temperature

6: BBr₃ / CH₂Cl₂ / 1 h / Ambient temperature

7: 2 N ethanol. NaOH / 4 h / Ambient temperature

8: p-toluenesulfonic acid / toluene / 3 h / Heating

With hydrogenchloride; potassium hydroxide; sodium hydroxide; thionyl chloride; water; boron tribromide; tin(IV) chloride; toluene-4-sulfonic acid; sulfur; In ethanol; dichloromethane; toluene;
DOI:10.1021/jm00144a019

Reference yield:

: 57568-40-8
4-cyclohexyl-2-methoxyphenylacetic acid

: 60986-89-2
5-chloro-6-cyclohexyl-2,3-dihydrobenzofuran-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: HCl(g) / 0.5 h

2: SOCl₂ / CH₂Cl₂ / Ambient temperature

3: BBr₃ / CH₂Cl₂ / 1 h / Ambient temperature

4: 2 N ethanol. NaOH / 4 h / Ambient temperature

5: p-toluenesulfonic acid / toluene / 3 h / Heating

With hydrogenchloride; sodium hydroxide; thionyl chloride; boron tribromide; toluene-4-sulfonic acid; In dichloromethane; toluene;
DOI:10.1021/jm00144a019