2'-O-(tert-butyldimethylsilyl)-6α-trifluoromethanesulfuryl-7-epipaclitaxel

Base Information

Chemical Name:2'-O-(tert-butyldimethylsilyl)-6α-trifluoromethanesulfuryl-7-epipaclitaxel
CAS No.:188528-70-3
Molecular Formula:C₅₄H₆₄F₃NO₁₇SSi
Molecular Weight:1116.25
Hs Code.:

Synonyms:2'-O-(tert-butyldimethylsilyl)-6α-trifluoromethanesulfuryl-7-epipaclitaxel

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2'-O-(tert-butyldimethylsilyl)-6α-trifluoromethanesulfuryl-7-epipaclitaxel

Chemical Property:

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Technology Process of 2'-O-(tert-butyldimethylsilyl)-6α-trifluoromethanesulfuryl-7-epipaclitaxel

There total 4 articles about 2'-O-(tert-butyldimethylsilyl)-6α-trifluoromethanesulfuryl-7-epipaclitaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 421-83-0
trifluoromethane sulfonyl chloride

: 165065-08-7
2'-O-(tert-butyldimethylsilyl)-6α-hydroxy-7-epipaclitaxel

: 188528-70-3
2'-O-(tert-butyldimethylsilyl)-6α-trifluoromethanesulfuryl-7-epipaclitaxel

Guidance literature:: With dmap; In dichloromethane; for 1h; Ambient temperature;
DOI:10.1016/S0040-4020(97)00074-4

Reference yield:

: 114655-02-6
2'-O-(tert-butyldimethylsilyl)paclitaxel

: 188528-70-3
2'-O-(tert-butyldimethylsilyl)-6α-trifluoromethanesulfuryl-7-epipaclitaxel

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / 4-dimethylaminopyridine / CH₂Cl₂ / 2.5 h / Ambient temperature

2: 86 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene / CH₂Cl₂ / 4 h / 40 °C

3: 78 percent / osmium tetraoxide, 4-methyl morpholine-N-oxide / tetrahydrofuran; H₂O; 2-methyl-propan-2-ol / 9 h / Ambient temperature

4: 96 percent / dimethylaminopyridine / CH₂Cl₂ / 1 h / Ambient temperature

With dmap; osmium(VIII) oxide; 4-methylmorpholine N-oxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;
DOI:10.1016/S0040-4020(97)00074-4

Reference yield:

: 165065-02-1
2'-O-(tert-butyldimethylsilyl)-6,7-dehydropaclitaxel

: 188528-70-3
2'-O-(tert-butyldimethylsilyl)-6α-trifluoromethanesulfuryl-7-epipaclitaxel

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / osmium tetraoxide, 4-methyl morpholine-N-oxide / tetrahydrofuran; H₂O; 2-methyl-propan-2-ol / 9 h / Ambient temperature

2: 96 percent / dimethylaminopyridine / CH₂Cl₂ / 1 h / Ambient temperature

With dmap; osmium(VIII) oxide; 4-methylmorpholine N-oxide; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;
DOI:10.1016/S0040-4020(97)00074-4