3-nitro-N-[3-(trifluoromethyl)phenyl]benzamide

Base Information

• Chemical Name: 3-nitro-N-[3-(trifluoromethyl)phenyl]benzamide
• CAS No.: 180631-67-8
• Molecular Formula: C₁₄H₉F₃N₂O₃
• Molecular Weight: 310.232
• Mol file: 180631-67-8.mol

Synonyms:3-nitro-N-(3-(trifluoromethyl)phenyl)benzamide

Chemical Property of 3-nitro-N-[3-(trifluoromethyl)phenyl]benzamide

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

3-nitro-N-[3-(trifluoromethyl)phenyl]benzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-nitro-N-[3-(trifluoromethyl)phenyl]benzamide

There total 2 articles about 3-nitro-N-[3-(trifluoromethyl)phenyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3-trifluoromethylaniline (98-16-8) + m-nitrobenzoic acid chloride (121-90-4) → 3-nitro-N-(3-(trifluoromethyl)phenyl)benzamide (180631-67-8)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1021/jm701191z

Reference yield: 79.0%

3-trifluoromethylaniline (98-16-8) + 3-nitrobenzoic acid (121-92-6) → 3-nitro-N-(3-(trifluoromethyl)phenyl)benzamide (180631-67-8)

Guidance literature:

With triethylamine; In dichloromethane; at 25 ℃; for 15h; Inert atmosphere; Schlenk technique;

DOI:10.1021/jm5009242

Reference yield: 98.0%

3-nitro-N-(3-(trifluoromethyl)phenyl)benzamide (180631-67-8) → 3-amino-N-(3-(trifluoromethyl)phenyl)benzamide (328107-22-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; under 750.075 Torr;

DOI:10.1021/jm701191z

upstream raw materials:

3-trifluoromethylaniline

m-nitrobenzoic acid chloride

3-nitrobenzoic acid

Downstream raw materials:

3-amino-N-(3-(trifluoromethyl)phenyl)benzamide

Refernces

• 1、 -. "2-Amino-1-phenyl-pyrrolo[3,2-b]quinoxaline-3-carboxamide derivates". Paragraph 0135; 0138. . Retrieved 2015/11/16.
• 2、 Kakuta, Hiroki,Zheng, Xiaoxia,Oda, Hiroyuki,Harada, Shun,Sugimoto, Yukio,Sasaki, Kenji,Tai, Akihiro. "Cyclooxygenase-1-selective inhibitors are attractive candidates for analgesics that do not cause gastric damage. Design and in vitro/in vivo evaluation of a benzamide-type cyclooxygenase-1 selective inhibitor". . p. 2400 - 2411. Retrieved 2008/12/22.