3-amino-6-bromo-N'-(2-phenylacetyl)-5-(trifluoromethyl)picolinohydrazide

Base Information

• Chemical Name: 3-amino-6-bromo-N'-(2-phenylacetyl)-5-(trifluoromethyl)picolinohydrazide
• CAS No.: 1427262-61-0
• Molecular Formula: C₁₅H₁₂BrF₃N₄O₂
• Molecular Weight: 417.185
• Mol file: 1427262-61-0.mol

Synonyms:3-amino-6-bromo-N'-(2-phenylacetyl)-5-(trifluoromethyl)picolinohydrazide

Chemical Property of 3-amino-6-bromo-N'-(2-phenylacetyl)-5-(trifluoromethyl)picolinohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-amino-6-bromo-N'-(2-phenylacetyl)-5-(trifluoromethyl)picolinohydrazide

There total 6 articles about 3-amino-6-bromo-N'-(2-phenylacetyl)-5-(trifluoromethyl)picolinohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenylacetic acid (103-82-2) + 3-amino-6-bromo-5-(trifluoromethyl)picolinohydrazide (1427262-62-1) → 3-amino-6-bromo-N'-(2-phenylacetyl)-5-(trifluoromethyl)picolinohydrazide (1427262-61-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 1h;

Reference yield:

3-amino-6-bromo-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester (866775-18-0) → 3-amino-6-bromo-N'-(2-phenylacetyl)-5-(trifluoromethyl)picolinohydrazide (1427262-61-0)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / methanol / 5.5 h / Reflux

2: N-ethyl-N,N-diisopropylamine; HATU / 1-methyl-pyrrolidin-2-one / 1 h / 20 °C

With hydrazine hydrate; N-ethyl-N,N-diisopropylamine; HATU; In 1-methyl-pyrrolidin-2-one; methanol;

Reference yield:

3-nitro-5-trifluoromethylpyridin-2-ol (33252-64-1) → 3-amino-6-bromo-N'-(2-phenylacetyl)-5-(trifluoromethyl)picolinohydrazide (1427262-61-0)

Guidance literature:

Multi-step reaction with 6 steps

1.1: phosphorus(V) oxybromide / acetonitrile / 20 °C / Reflux

2.1: tetrabutylammomium bromide; copper(l) cyanide / toluene / 9 h / Reflux

3.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 18 h

3.2: 24 h / Reflux

3.3: 84 h / Reflux

4.1: sulfuric acid; bromine / water; acetic acid / 20 h / 20 °C

5.1: hydrazine hydrate / methanol / 5.5 h / Reflux

6.1: N-ethyl-N,N-diisopropylamine; HATU / 1-methyl-pyrrolidin-2-one / 1 h / 20 °C

With sulfuric acid; palladium 10% on activated carbon; tetrabutylammomium bromide; hydrogen; bromine; copper(l) cyanide; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; HATU; phosphorus(V) oxybromide; In 1-methyl-pyrrolidin-2-one; methanol; water; acetic acid; ethyl acetate; toluene; acetonitrile;

upstream raw materials:

3-amino-6-bromo-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester

phenylacetic acid

3-amino-6-bromo-5-(trifluoromethyl)picolinohydrazide

3-amino-6-(2,6-difluorophenyl)-5-trifluoromethyl-2-pyridinecarboxylicacid

Downstream raw materials:

2-(5-benzyl-1,3,4-oxadiazol-2-yl)-6-bromo-5-(trifluoromethyl)pyridin-3-amine

Refernces