3-amino-6-bromo-N'-(2-phenylacetyl)-5-(trifluoromethyl)picolinohydrazide

Base Information

Chemical Name:3-amino-6-bromo-N'-(2-phenylacetyl)-5-(trifluoromethyl)picolinohydrazide
CAS No.:1427262-61-0
Molecular Formula:C₁₅H₁₂BrF₃N₄O₂
Molecular Weight:417.185
Hs Code.:

Synonyms:3-amino-6-bromo-N'-(2-phenylacetyl)-5-(trifluoromethyl)picolinohydrazide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-amino-6-bromo-N'-(2-phenylacetyl)-5-(trifluoromethyl)picolinohydrazide

Chemical Property:

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Technology Process of 3-amino-6-bromo-N'-(2-phenylacetyl)-5-(trifluoromethyl)picolinohydrazide

There total 6 articles about 3-amino-6-bromo-N'-(2-phenylacetyl)-5-(trifluoromethyl)picolinohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 103-82-2
phenylacetic acid

: 1427262-62-1
3-amino-6-bromo-5-(trifluoromethyl)picolinohydrazide

: 1427262-61-0
3-amino-6-bromo-N'-(2-phenylacetyl)-5-(trifluoromethyl)picolinohydrazide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 1h;

Reference yield:

: 866775-18-0
3-amino-6-bromo-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester

: 1427262-61-0
3-amino-6-bromo-N'-(2-phenylacetyl)-5-(trifluoromethyl)picolinohydrazide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / methanol / 5.5 h / Reflux

2: N-ethyl-N,N-diisopropylamine; HATU / 1-methyl-pyrrolidin-2-one / 1 h / 20 °C

With hydrazine hydrate; N-ethyl-N,N-diisopropylamine; HATU; In 1-methyl-pyrrolidin-2-one; methanol;

Reference yield:

: 33252-64-1
3-nitro-5-trifluoromethylpyridin-2-ol

: 1427262-61-0
3-amino-6-bromo-N'-(2-phenylacetyl)-5-(trifluoromethyl)picolinohydrazide

Guidance literature:: Multi-step reaction with 6 steps

1.1: phosphorus(V) oxybromide / acetonitrile / 20 °C / Reflux

2.1: tetrabutylammomium bromide; copper(l) cyanide / toluene / 9 h / Reflux

3.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 18 h

3.2: 24 h / Reflux

3.3: 84 h / Reflux

4.1: sulfuric acid; bromine / water; acetic acid / 20 h / 20 °C

5.1: hydrazine hydrate / methanol / 5.5 h / Reflux

6.1: N-ethyl-N,N-diisopropylamine; HATU / 1-methyl-pyrrolidin-2-one / 1 h / 20 °C

With sulfuric acid; palladium 10% on activated carbon; tetrabutylammomium bromide; hydrogen; bromine; copper(l) cyanide; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; HATU; phosphorus(V) oxybromide; In 1-methyl-pyrrolidin-2-one; methanol; water; acetic acid; ethyl acetate; toluene; acetonitrile;