(S)-Hydroxy-((R)-2-phenyl-4,5-dihydro-oxazol-4-yl)-thioacetic acid S-tert-butyl ester

Base Information

Chemical Name:(S)-Hydroxy-((R)-2-phenyl-4,5-dihydro-oxazol-4-yl)-thioacetic acid S-tert-butyl ester
CAS No.:152495-86-8
Molecular Formula:C₁₅H₁₉NO₃S
Molecular Weight:293.387
Hs Code.:

Synonyms:(S)-Hydroxy-((R)-2-phenyl-4,5-dihydro-oxazol-4-yl)-thioacetic acid S-tert-butyl ester

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Chemical Property of (S)-Hydroxy-((R)-2-phenyl-4,5-dihydro-oxazol-4-yl)-thioacetic acid S-tert-butyl ester

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Technology Process of (S)-Hydroxy-((R)-2-phenyl-4,5-dihydro-oxazol-4-yl)-thioacetic acid S-tert-butyl ester

There total 1 articles about (S)-Hydroxy-((R)-2-phenyl-4,5-dihydro-oxazol-4-yl)-thioacetic acid S-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 102614-13-1
2-phenyl-4(S)-<2-((2-methyl-2-propyl)thio)-2-oxoethyl>-2-oxazoline

: 152495-86-8
(S)-Hydroxy-((R)-2-phenyl-4,5-dihydro-oxazol-4-yl)-thioacetic acid S-tert-butyl ester

Guidance literature:: With sodium hexamethyldisilazane; N-(benzenesulfonyl)-3-phenyloxaziridine; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; 1.) -78 deg C;
DOI:10.1021/jo00075a007

Reference yield:

: 152495-86-8
(S)-Hydroxy-((R)-2-phenyl-4,5-dihydro-oxazol-4-yl)-thioacetic acid S-tert-butyl ester

: C₁₇H₂₇NO₃Si

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine

2: NaBH₄ / 48 h

3: KH / tetrahydrofuran

With pyridine; sodium tetrahydroborate; potassium hydride; In tetrahydrofuran;
DOI:10.1021/jo00075a007

Reference yield:

: 152495-86-8
(S)-Hydroxy-((R)-2-phenyl-4,5-dihydro-oxazol-4-yl)-thioacetic acid S-tert-butyl ester

: (1S,2S)-1-(tert-Butyl-dimethyl-silanyloxy)-1-((R)-2-phenyl-4,5-dihydro-oxazol-4-yl)-propan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine

2: 65 percent / tetrahydrofuran / -78 °C

3: DIBAL / tetrahydrofuran / -78 °C

With pyridine; diisobutylaluminium hydride; In tetrahydrofuran;
DOI:10.1021/jo00075a007