Technology Process of 2,3-dideoxy-6-O-(3,5-difluorobenzyl)-2-methyl-D-glucono-1,4-lactone
There total 6 articles about 2,3-dideoxy-6-O-(3,5-difluorobenzyl)-2-methyl-D-glucono-1,4-lactone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2,3-dideoxy-2-methyl-D-glucono-1,4-lactone;
With
di(n-butyl)tin oxide;
In
toluene;
for 5h;
Heating / reflux;
1-bromomethyl-3,5-difluoro-benzene;
With
tetrabutylammomium bromide;
In
toluene;
at 90 ℃;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C
1.2: 2 h / -78 °C
1.3: 20 °C
2.1: hydrogen / palladium on activated charcoal / ethanol
3.1: di(n-butyl)tin oxide / toluene / 5 h / Heating / reflux
3.2: 90 °C
With
hydrogen; di(n-butyl)tin oxide; lithium diisopropyl amide;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; toluene;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: tetrahydrofuran / Heating / reflux
2.1: tri-n-butyl-tin hydride / toluene / 2.5 h / 110 °C / Heating / reflux
3.1: boron trifluoride diethyl etherate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / 0 - 20 °C
4.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C
4.2: 2 h / -78 °C
4.3: 20 °C
5.1: hydrogen / palladium on activated charcoal / ethanol
6.1: di(n-butyl)tin oxide / toluene / 5 h / Heating / reflux
6.2: 90 °C
With
boron trifluoride diethyl etherate; hydrogen; tri-n-butyl-tin hydride; di(n-butyl)tin oxide; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dichloromethane; toluene;
