(4R,6S)-4-(tert-Butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-cyclohex-1-enecarboxylic acid methyl ester

Base Information

Chemical Name:(4R,6S)-4-(tert-Butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-cyclohex-1-enecarboxylic acid methyl ester
CAS No.:142562-64-9
Molecular Formula:C₂₁H₄₂O₄Si₂
Molecular Weight:414.733
Hs Code.:

Synonyms:(4R,6S)-4-(tert-Butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-cyclohex-1-enecarboxylic acid methyl ester

Suppliers and Price of (4R,6S)-4-(tert-Butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-cyclohex-1-enecarboxylic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4R,6S)-4-(tert-Butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-cyclohex-1-enecarboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4R,6S)-4-(tert-Butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-cyclohex-1-enecarboxylic acid methyl ester

There total 18 articles about (4R,6S)-4-(tert-Butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-cyclohex-1-enecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 69739-34-0
t-butyldimethylsiyl triflate

: 142508-70-1,142562-61-6,142562-62-7
(4S,6R)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-4-hydroxy-cyclohex-1-enecarboxylic acid methyl ester

: 142508-72-3,142562-64-9,142562-65-0
(4R,6S)-4-(tert-Butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-cyclohex-1-enecarboxylic acid methyl ester

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; for 0.5h;
DOI:10.1021/jm00095a026

Reference yield:

: 19978-32-6
3-bromo-2H-pyran-2-one

: 142562-64-9
(4R,6S)-4-(tert-Butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-cyclohex-1-enecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

2: 1.) tributyltin hydride, AIBN, DBU / 1.) benzene, reflux, 2 h, 2.) THF, -35 deg C - 25 deg C, 11 h

3: 46 percent / 1,3-dicyclohexylcarbodiimide, 4-(dimethylamino)-pyridine / diethyl ether / 12 h / Ambient temperature

4: 91 percent / sodium methoxide / methanol; tetrahydrofuran / 8 h

5: 2,6-lutidine / CH₂Cl₂ / 0.5 h

With 2,6-dimethylpyridine; dmap; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium methylate; 1,8-diazabicyclo[5.4.0]undec-7-ene; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1021/jm00095a026

Reference yield:

: 19978-32-6
3-bromo-2H-pyran-2-one

: 142508-72-3,142562-64-9,142562-65-0
(4R,6S)-4-(tert-Butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-cyclohex-1-enecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

2: 1.) tributyltin hydride, AIBN, DBU / 1.) benzene, reflux, 2 h, 2.) THF, -35 deg C - 25 deg C, 11 h

3: 86 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h

With 2,6-dimethylpyridine; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane;
DOI:10.1021/jm00095a026