N-methyl-N-(3-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethylpyrimidin-4-ylamino]methyl}pyridin-2-yl)methanesulfonamide tosylate

Base Information

Chemical Name:N-methyl-N-(3-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethylpyrimidin-4-ylamino]methyl}pyridin-2-yl)methanesulfonamide tosylate
CAS No.:939791-40-9
Molecular Formula:C₇H₈O₃S*C₂₁H₂₀F₃N₇O₃S
Molecular Weight:679.701
Hs Code.:

N-methyl-N-(3-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethylpyrimidin-4-ylamino]methyl}pyridin-2-yl)methanesulfonamide tosylate

Synonyms:N-methyl-N-(3-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethylpyrimidin-4-ylamino]methyl}pyridin-2-yl)methanesulfonamide tosylate

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Chemical Property of N-methyl-N-(3-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethylpyrimidin-4-ylamino]methyl}pyridin-2-yl)methanesulfonamide tosylate

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Technology Process of N-methyl-N-(3-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethylpyrimidin-4-ylamino]methyl}pyridin-2-yl)methanesulfonamide tosylate

There total 5 articles about N-methyl-N-(3-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethylpyrimidin-4-ylamino]methyl}pyridin-2-yl)methanesulfonamide tosylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 717907-75-0
PF-562,271

: 939791-40-9
N-methyl-N-(3-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethylpyrimidin-4-ylamino]methyl}pyridin-2-yl)methanesulfonamide tosylate

Guidance literature:: With toluene-4-sulfonic acid; In ethanol; at 20 ℃; for 12h;

Reference yield:

: 3932-97-6
2,4-dichloro-5-trifluoromethylpyrimidine

: 939791-40-9
N-methyl-N-(3-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethylpyrimidin-4-ylamino]methyl}pyridin-2-yl)methanesulfonamide tosylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: zinc dibromide / 1,2-dichloro-ethane; tert-butyl alcohol / 0.5 h

1.2: 35 °C / Industry scale

2.1: diisopropylamine / isopropyl alcohol; toluene / 6.4 h / 10 - 90 °C / Industry scale

3.1: toluene-4-sulfonic acid / ethanol / 12 h / 20 °C

With toluene-4-sulfonic acid; diisopropylamine; zinc dibromide; In ethanol; 1,2-dichloro-ethane; isopropyl alcohol; toluene; tert-butyl alcohol;

Reference yield:

: 54-20-6
5-trifluoromethyluracil

: 939791-40-9
N-methyl-N-(3-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethylpyrimidin-4-ylamino]methyl}pyridin-2-yl)methanesulfonamide tosylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate; phosphoric acid / water / 22 h / 20 - 100 °C / Industry scale

2.1: zinc dibromide / 1,2-dichloro-ethane; tert-butyl alcohol / 0.5 h

2.2: 35 °C / Industry scale

3.1: diisopropylamine / isopropyl alcohol; toluene / 6.4 h / 10 - 90 °C / Industry scale

4.1: toluene-4-sulfonic acid / ethanol / 12 h / 20 °C

With phosphoric acid; toluene-4-sulfonic acid; diisopropylamine; N-ethyl-N,N-diisopropylamine; zinc dibromide; trichlorophosphate; In ethanol; water; 1,2-dichloro-ethane; isopropyl alcohol; toluene; tert-butyl alcohol;