6-(1-adamantyl)-3-(t-butyldimethylsilyloxy)-2-iodophenyl trifluoromethanesulfonate

Base Information

Chemical Name:6-(1-adamantyl)-3-(t-butyldimethylsilyloxy)-2-iodophenyl trifluoromethanesulfonate
CAS No.:1271334-03-2
Molecular Formula:C₂₃H₃₂F₃IO₄SSi
Molecular Weight:616.556
Hs Code.:

Synonyms:6-(1-adamantyl)-3-(t-butyldimethylsilyloxy)-2-iodophenyl trifluoromethanesulfonate

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Chemical Property of 6-(1-adamantyl)-3-(t-butyldimethylsilyloxy)-2-iodophenyl trifluoromethanesulfonate

Chemical Property:

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Technology Process of 6-(1-adamantyl)-3-(t-butyldimethylsilyloxy)-2-iodophenyl trifluoromethanesulfonate

There total 4 articles about 6-(1-adamantyl)-3-(t-butyldimethylsilyloxy)-2-iodophenyl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 1271325-21-3
6-(1-adamantyl)-3-(t-butyldimethylsilyloxy)-2-iodophenol

: 1271334-03-2
6-(1-adamantyl)-3-(t-butyldimethylsilyloxy)-2-iodophenyl trifluoromethanesulfonate

Guidance literature:: 6-(1-adamantyl)-3-(t-butyldimethylsilyloxy)-2-iodophenol; With sodium hydride; In diethyl ether; mineral oil; at 0 ℃; Inert atmosphere; Reflux;

trifluoromethylsulfonic anhydride; at 0 ℃; for 0.5h; Inert atmosphere;
DOI:10.1039/c0cc03025b

Reference yield:

: 74131-25-2
4-(1-adamantyl)benzene-1,3-diol

: 1271334-03-2
6-(1-adamantyl)-3-(t-butyldimethylsilyloxy)-2-iodophenyl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: iodine; sodium hydrogencarbonate / tetrahydrofuran; water / 0 - 20 °C

2.1: 1H-imidazole / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

3.1: sodium hydride / diethyl ether; mineral oil / 0 °C / Inert atmosphere; Reflux

3.2: 0.5 h / 0 °C / Inert atmosphere

With 1H-imidazole; iodine; sodium hydride; sodium hydrogencarbonate; In tetrahydrofuran; diethyl ether; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1039/c0cc03025b

Reference yield:

: 108-46-3
recorcinol

: 1271334-03-2
6-(1-adamantyl)-3-(t-butyldimethylsilyloxy)-2-iodophenyl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: Acidic conditions

2.1: iodine; sodium hydrogencarbonate / tetrahydrofuran; water / 0 - 20 °C

3.1: 1H-imidazole / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

4.1: sodium hydride / diethyl ether; mineral oil / 0 °C / Inert atmosphere; Reflux

4.2: 0.5 h / 0 °C / Inert atmosphere

With 1H-imidazole; iodine; sodium hydride; sodium hydrogencarbonate; In tetrahydrofuran; diethyl ether; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1039/c0cc03025b