4-N-[Nα-(benzyloxycarbonyl)valylprolylvalylprolyl]-3',5'-bis-O-(tert-butyldimethylsilyl)-1-β-D-arabinofuranosyladenine

Base Information

• Chemical Name: 4-N-[Nα-(benzyloxycarbonyl)valylprolylvalylprolyl]-3',5'-bis-O-(tert-butyldimethylsilyl)-1-β-D-arabinofuranosyladenine
• CAS No.: 1203578-20-4
• Molecular Formula: C₅₀H₇₉N₉O₁₀Si₂
• Molecular Weight: 1022.4
• Mol file: 1203578-20-4.mol

Synonyms:4-N-[Nα-(benzyloxycarbonyl)valylprolylvalylprolyl]-3',5'-bis-O-(tert-butyldimethylsilyl)-1-β-D-arabinofuranosyladenine

Chemical Property of 4-N-[Nα-(benzyloxycarbonyl)valylprolylvalylprolyl]-3',5'-bis-O-(tert-butyldimethylsilyl)-1-β-D-arabinofuranosyladenine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-N-[Nα-(benzyloxycarbonyl)valylprolylvalylprolyl]-3',5'-bis-O-(tert-butyldimethylsilyl)-1-β-D-arabinofuranosyladenine

There total 1 articles about 4-N-[Nα-(benzyloxycarbonyl)valylprolylvalylprolyl]-3',5'-bis-O-(tert-butyldimethylsilyl)-1-β-D-arabinofuranosyladenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

Cbz-Val-Pro-Val-Pro-OH (791111-79-0) + 9-<3,5-bis-O-(tert-butyldimethylsilyl)-β-D-arabinofuranosyl>adenine (82870-42-6) → 4-N-[Nα-(benzyloxycarbonyl)valylprolylvalylprolyl]-3',5'-bis-O-(tert-butyldimethylsilyl)-1-β-D-arabinofuranosyladenine (1203578-20-4)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In dichloromethane; at 90 ℃;

DOI:10.1021/jm901590f

Reference yield: 59.0%

4-N-[Nα-(benzyloxycarbonyl)valylprolylvalylprolyl]-3',5'-bis-O-(tert-butyldimethylsilyl)-1-β-D-arabinofuranosyladenine (1203578-20-4) → 4-N-[Nα-(benzyloxycarbonyl)valylprolylvalylprolyl]-1-β-D-arabinofuranosyladenine (1203578-21-5)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/jm901590f

upstream raw materials:

Cbz-Val-Pro-Val-Pro-OH

9-<3,5-bis-O-(tert-butyldimethylsilyl)-β-D-arabinofuranosyl>adenine

Downstream raw materials:

4-N-[Nα-(benzyloxycarbonyl)valylprolylvalylprolyl]-1-β-D-arabinofuranosyladenine