9-(1-benzyl-piperidin-4-yl)-2-chloro-6-morpholin-4-yl-9H-purine

Base Information

• Chemical Name: 9-(1-benzyl-piperidin-4-yl)-2-chloro-6-morpholin-4-yl-9H-purine
• CAS No.: 1062205-49-5
• Molecular Formula: C₂₁H₂₅ClN₆O
• Molecular Weight: 412.922
• Mol file: 1062205-49-5.mol

Synonyms:9-(1-benzyl-piperidin-4-yl)-2-chloro-6-morpholin-4-yl-9H-purine

Chemical Property of 9-(1-benzyl-piperidin-4-yl)-2-chloro-6-morpholin-4-yl-9H-purine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 9-(1-benzyl-piperidin-4-yl)-2-chloro-6-morpholin-4-yl-9H-purine

There total 1 articles about 9-(1-benzyl-piperidin-4-yl)-2-chloro-6-morpholin-4-yl-9H-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(2-chloro-9H-purin-6-yl)morpholine (4010-81-5) + 1-benzyl-4-hydroxypiperidine (4727-72-4) → 9-(1-benzyl-piperidin-4-yl)-2-chloro-6-morpholin-4-yl-9H-purine (1062205-49-5)

Guidance literature:

1-benzyl-4-hydroxypiperidine; With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; for 0.5h;

4-(2-chloro-9H-purin-6-yl)morpholine; In tetrahydrofuran; for 72h;

Reference yield: 48.0%

(2-aminopyrimidin-5-yl)boronic acid (936250-22-5) + 9-(1-benzyl-piperidin-4-yl)-2-chloro-6-morpholin-4-yl-9H-purine (1062205-49-5) → 5-[9-(1-benzylpiperidin-4-yl)-6-morpholin-4-yl-9H-purin-2-yl]pyrimidin-2-amine (1062204-37-8)

Guidance literature:

With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 175 ℃; for 0.166667 - 0.333333h;

Reference yield:

9-(1-benzyl-piperidin-4-yl)-2-chloro-6-morpholin-4-yl-9H-purine (1062205-49-5) + [3-(hydroxymethyl)phenyl]boronic acid (87199-15-3) → {3-[9-(1-benzylpiperidin-4-yl)-6-morpholin-4-yl-9H-purin-2-yl]phenyl}methanol (1062204-36-7)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 175 ℃; for 0.166667h; Microwave irradiation;

upstream raw materials:

4-(2-chloro-9H-purin-6-yl)morpholine

1-benzyl-4-hydroxypiperidine

Downstream raw materials:

{3-[9-(1-benzylpiperidin-4-yl)-6-morpholin-4-yl-9H-purin-2-yl]phenyl}methanol

5-[9-(1-benzylpiperidin-4-yl)-6-morpholin-4-yl-9H-purin-2-yl]pyrimidin-2-amine

3-(9-(1-benzylpiperidin-4-yl)-6-morpholino-9H-purin-2-yl)phenol