Toluene-4-sulfonic acid (S)-3-[2-[(1R,3aS,7aR)-1-((R)-5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-4-methylene-cyclohexyl ester

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Chemical Name:Toluene-4-sulfonic acid (S)-3-[2-[(1R,3aS,7aR)-1-((R)-5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-4-methylene-cyclohexyl ester
CAS No.:69822-72-6
Molecular Formula:C₃₄H₅₀O₄S
Molecular Weight:554.835
Hs Code.:

Toluene-4-sulfonic acid (S)-3-[2-[(1R,3aS,7aR)-1-((R)-5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-4-methylene-cyclohexyl ester

Synonyms:Toluene-4-sulfonic acid (S)-3-[2-[(1R,3aS,7aR)-1-((R)-5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-4-methylene-cyclohexyl ester

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Chemical Property of Toluene-4-sulfonic acid (S)-3-[2-[(1R,3aS,7aR)-1-((R)-5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-4-methylene-cyclohexyl ester

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Technology Process of Toluene-4-sulfonic acid (S)-3-[2-[(1R,3aS,7aR)-1-((R)-5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-4-methylene-cyclohexyl ester

There total 2 articles about Toluene-4-sulfonic acid (S)-3-[2-[(1R,3aS,7aR)-1-((R)-5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-4-methylene-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 19356-17-3
calcidiol

: 98-59-9
p-toluenesulfonyl chloride

: 69822-72-6
Toluene-4-sulfonic acid (S)-3-[2-[(1R,3aS,7aR)-1-((R)-5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-4-methylene-cyclohexyl ester

Guidance literature:: With pyridine; at 4 ℃;
DOI:10.1006/bioo.1994.1013

Reference yield:

: 19356-17-3
25-Hydroxyvitamin D₃

: 98-59-9
p-toluenesulfonyl chloride

: 69822-72-6
25-Hydroxyvitamin D₃ tosylate

Guidance literature:: In pyridine; at 3 ℃; for 24h;
DOI:10.1021/jo01304a022

Reference yield:

: 69822-72-6
Toluene-4-sulfonic acid (S)-3-[2-[(1R,3aS,7aR)-1-((R)-5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-4-methylene-cyclohexyl ester

: 157750-00-0
(5Z,7E,1S,3R,10S)-3-acetoxy-9,10-seco-5,7-cholestadiene-1,25-diol

Guidance literature:: Multi-step reaction with 4 steps

1: KHCO₃ / 55 °C

2: t-BuOOH, SeO₂, pyridine / CH₂Cl₂

3: 40 percent / 0.25 h / 55 °C

4: 78 percent / H₂, tris(triphenylphosphine)rhodium chloride / benzene / 3 h / Ambient temperature

With pyridine; tert.-butylhydroperoxide; Wilkinson's catalyst; selenium(IV) oxide; hydrogen; potassium hydrogencarbonate; In dichloromethane; benzene;
DOI:10.1006/bioo.1994.1013