3-{4-[2-((R)-3-Hydroxy-pyrrolidin-1-yl)-ethylamino]-1-methyl-cyclohexyl}-benzonitrile

Base Information

• Chemical Name: 3-{4-[2-((R)-3-Hydroxy-pyrrolidin-1-yl)-ethylamino]-1-methyl-cyclohexyl}-benzonitrile
• CAS No.: 869708-40-7
• Molecular Formula: C₂₀H₂₉N₃O
• Molecular Weight: 327.47
• Mol file: 869708-40-7.mol

Synonyms:3-{4-[2-((R)-3-Hydroxy-pyrrolidin-1-yl)-ethylamino]-1-methyl-cyclohexyl}-benzonitrile

Chemical Property of 3-{4-[2-((R)-3-Hydroxy-pyrrolidin-1-yl)-ethylamino]-1-methyl-cyclohexyl}-benzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-{4-[2-((R)-3-Hydroxy-pyrrolidin-1-yl)-ethylamino]-1-methyl-cyclohexyl}-benzonitrile

There total 5 articles about 3-{4-[2-((R)-3-Hydroxy-pyrrolidin-1-yl)-ethylamino]-1-methyl-cyclohexyl}-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

1-(2-aminoethyl)-3-(R)-hydroxy-pyrrolidine (672325-36-9,540787-75-5) + 3-(1-methyl-4-oxo-cyclohexyl)-benzonitrile (849697-66-1) → 3-{4-[2-((R)-3-Hydroxy-pyrrolidin-1-yl)-ethylamino]-1-methyl-cyclohexyl}-benzonitrile (869708-40-7)

Guidance literature:

With sodium tris(acetoxy)borohydride; In dichloromethane; Heating;

DOI:10.1021/jm049035q

Reference yield:

3-(1-methyl-4-oxo-cyclohex-2-enyl)-benzonitrile (849697-65-0) → 3-{4-[2-((R)-3-Hydroxy-pyrrolidin-1-yl)-ethylamino]-1-methyl-cyclohexyl}-benzonitrile (869708-40-7)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen / Pt/C / ethyl acetate / 2327.17 Torr

2: 0.36 g / Dess-Martin periodinane; pyridine / CH₂Cl₂ / 20 °C

3: sodium triacetoxyborohydride / CH₂Cl₂ / 24 h / Heating

With pyridine; hydrogen; sodium tris(acetoxy)borohydride; Dess-Martin periodane; platinum on activated charcoal; In dichloromethane; ethyl acetate;

DOI:10.1016/j.bmc.2005.12.046

Reference yield:

3-(1-methyl-2-oxo-ethyl)-benzonitrile (849697-64-9) → 3-{4-[2-((R)-3-Hydroxy-pyrrolidin-1-yl)-ethylamino]-1-methyl-cyclohexyl}-benzonitrile (869708-40-7)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium hydroxide / ethanol; diethyl ether / 20 °C

2: hydrogen / Pt/C / ethyl acetate / 2327.17 Torr

3: 0.36 g / Dess-Martin periodinane; pyridine / CH₂Cl₂ / 20 °C

4: sodium triacetoxyborohydride / CH₂Cl₂ / 24 h / Heating

With pyridine; potassium hydroxide; hydrogen; sodium tris(acetoxy)borohydride; Dess-Martin periodane; platinum on activated charcoal; In diethyl ether; ethanol; dichloromethane; ethyl acetate;

DOI:10.1016/j.bmc.2005.12.046

upstream raw materials:

1-(2-aminoethyl)-3-(R)-hydroxy-pyrrolidine

3-(1-methyl-4-oxo-cyclohexyl)-benzonitrile

3-(1-methyl-2-oxo-ethyl)-benzonitrile

3-(1-methyl-4-oxo-cyclohex-2-enyl)-benzonitrile