2-[2-(3-chlorophenyl)-4-(4-hydroxyphenyl)-1H-imidazol-1-yl]-N-(propan-2-yl)acetamide

Base Information

Chemical Name:2-[2-(3-chlorophenyl)-4-(4-hydroxyphenyl)-1H-imidazol-1-yl]-N-(propan-2-yl)acetamide
CAS No.:1431952-33-8
Molecular Formula:C₂₀H₂₀ClN₃O₂
Molecular Weight:369.851
Hs Code.:

Synonyms:2-[2-(3-chlorophenyl)-4-(4-hydroxyphenyl)-1H-imidazol-1-yl]-N-(propan-2-yl)acetamide

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Chemical Property of 2-[2-(3-chlorophenyl)-4-(4-hydroxyphenyl)-1H-imidazol-1-yl]-N-(propan-2-yl)acetamide

Chemical Property:

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Technology Process of 2-[2-(3-chlorophenyl)-4-(4-hydroxyphenyl)-1H-imidazol-1-yl]-N-(propan-2-yl)acetamide

There total 5 articles about 2-[2-(3-chlorophenyl)-4-(4-hydroxyphenyl)-1H-imidazol-1-yl]-N-(propan-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1431952-32-7
2-{2-(3-chlorophenyl)-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1H-imidazol-1-yl}-N-(propan-2-yl)acetamide

: 1431952-33-8
2-[2-(3-chlorophenyl)-4-(4-hydroxyphenyl)-1H-imidazol-1-yl]-N-(propan-2-yl)acetamide

Guidance literature:: With dihydrogen peroxide; In ethanol; water; at 20 ℃; for 24h;

Reference yield:

: 25412-62-8
3-chlorobenzimidamide

: 1431952-33-8
2-[2-(3-chlorophenyl)-4-(4-hydroxyphenyl)-1H-imidazol-1-yl]-N-(propan-2-yl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogencarbonate / tetrahydrofuran; water / 2 h / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 20 °C

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / dimethyl sulfoxide / 1.5 h / 100 °C / Inert atmosphere

4: dihydrogen peroxide / water; ethanol / 24 h / 20 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; dihydrogen peroxide; potassium acetate; sodium hydrogencarbonate; potassium carbonate; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 99-73-0,132309-76-3
para-bromophenacyl bromide

: 1431952-33-8
2-[2-(3-chlorophenyl)-4-(4-hydroxyphenyl)-1H-imidazol-1-yl]-N-(propan-2-yl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogencarbonate / tetrahydrofuran; water / 2 h / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 20 °C

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / dimethyl sulfoxide / 1.5 h / 100 °C / Inert atmosphere

4: dihydrogen peroxide / water; ethanol / 24 h / 20 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; dihydrogen peroxide; potassium acetate; sodium hydrogencarbonate; potassium carbonate; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;