(3-bromo-5-(1H-indol-4-yl)phenyl)(2-methyl-6-morpholinopyridin-4-yl)methanone

Base Information

Chemical Name:(3-bromo-5-(1H-indol-4-yl)phenyl)(2-methyl-6-morpholinopyridin-4-yl)methanone
CAS No.:1260030-05-4
Molecular Formula:C₂₅H₂₂BrN₃O₂
Molecular Weight:476.373
Hs Code.:

Synonyms:(3-bromo-5-(1H-indol-4-yl)phenyl)(2-methyl-6-morpholinopyridin-4-yl)methanone

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Chemical Property of (3-bromo-5-(1H-indol-4-yl)phenyl)(2-methyl-6-morpholinopyridin-4-yl)methanone

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Technology Process of (3-bromo-5-(1H-indol-4-yl)phenyl)(2-methyl-6-morpholinopyridin-4-yl)methanone

There total 6 articles about (3-bromo-5-(1H-indol-4-yl)phenyl)(2-methyl-6-morpholinopyridin-4-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 110-91-8,99108-56-2
morpholine

: 1260030-04-3
(3-bromo-5-(1H-indol-4-yl)phenyl)(2-chloro-6-methylpyridin-4-yl)methanone

: 1260030-05-4
(3-bromo-5-(1H-indol-4-yl)phenyl)(2-methyl-6-morpholinopyridin-4-yl)methanone

Guidance literature:: In 1,4-dioxane; at 120 ℃; for 3h; Microwave irradiation;
DOI:10.1021/jm100659v

Reference yield:

: 25462-85-5
2-chloro-6-methylpyridine-4-carboxylic acid

: 1260030-05-4
(3-bromo-5-(1H-indol-4-yl)phenyl)(2-methyl-6-morpholinopyridin-4-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: benzotriazol-1-ol / dichloromethane; N,N-dimethyl-formamide / 0.33 h / 0 °C

1.2: 0 - 20 °C

1.3: 16 h / 0 - 20 °C

2.1: n-butyllithium / diethyl ether / 1 h / -78 - -70 °C

2.2: 0.75 h / -70 - -25 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; water; toluene / 16 h / 70 °C / Inert atmosphere

4.1: 1,4-dioxane / 3 h / 120 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; sodium carbonate; benzotriazol-1-ol; In 1,4-dioxane; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 3.1: Suzuki coupling;
DOI:10.1021/jm100659v

Reference yield:

: 915412-70-3
(2-chloro-6-methylpyridin-4-yl)(3,5-dibromophenyl)methanone

: 1260030-05-4
(3-bromo-5-(1H-indol-4-yl)phenyl)(2-methyl-6-morpholinopyridin-4-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; water; toluene / 16 h / 70 °C / Inert atmosphere

2: 1,4-dioxane / 3 h / 120 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; ethanol; water; toluene; 1: Suzuki coupling;
DOI:10.1021/jm100659v