((S)-1-Phenyl-ethyl)-carbamic acid (S)-1-(4-fluoro-phenyl)-4-[4-(5-fluoro-pyrimidin-2-yl)-piperazin-1-yl]-butyl ester

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Chemical Name:((S)-1-Phenyl-ethyl)-carbamic acid (S)-1-(4-fluoro-phenyl)-4-[4-(5-fluoro-pyrimidin-2-yl)-piperazin-1-yl]-butyl ester
CAS No.:144317-75-9
Molecular Formula:C₂₇H₃₁F₂N₅O₂
Molecular Weight:495.572
Hs Code.:

Synonyms:((S)-1-Phenyl-ethyl)-carbamic acid (S)-1-(4-fluoro-phenyl)-4-[4-(5-fluoro-pyrimidin-2-yl)-piperazin-1-yl]-butyl ester

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Chemical Property of ((S)-1-Phenyl-ethyl)-carbamic acid (S)-1-(4-fluoro-phenyl)-4-[4-(5-fluoro-pyrimidin-2-yl)-piperazin-1-yl]-butyl ester

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Technology Process of ((S)-1-Phenyl-ethyl)-carbamic acid (S)-1-(4-fluoro-phenyl)-4-[4-(5-fluoro-pyrimidin-2-yl)-piperazin-1-yl]-butyl ester

There total 2 articles about ((S)-1-Phenyl-ethyl)-carbamic acid (S)-1-(4-fluoro-phenyl)-4-[4-(5-fluoro-pyrimidin-2-yl)-piperazin-1-yl]-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 14649-03-7
(S)-phenylethyl isocyanate

: 105565-56-8
4-[4-(5-fluoro-2-pyrimidinyl)-1-piperazinyl]-1-(4-fluorophenyl)butanol

: 144317-75-9
((S)-1-Phenyl-ethyl)-carbamic acid (S)-1-(4-fluoro-phenyl)-4-[4-(5-fluoro-pyrimidin-2-yl)-piperazin-1-yl]-butyl ester

Guidance literature:: In benzene; for 144h;
DOI:10.1021/jm00102a002

Reference yield:

: 99931-58-5
BMY 14786

: 144317-75-9
((S)-1-Phenyl-ethyl)-carbamic acid (S)-1-(4-fluoro-phenyl)-4-[4-(5-fluoro-pyrimidin-2-yl)-piperazin-1-yl]-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium borohydride / ethanol

2: 88 percent / benzene / 144 h

With sodium tetrahydroborate; In ethanol; benzene;
DOI:10.1021/jm00102a002