(Z)-2-((2-amino-4-chloro-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-6-oxo-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-5-ylidene)methyl)-N-(4-hydroxycyclohexyl)-1H-imidazole-4-carboxamide

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Chemical Name:(Z)-2-((2-amino-4-chloro-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-6-oxo-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-5-ylidene)methyl)-N-(4-hydroxycyclohexyl)-1H-imidazole-4-carboxamide
CAS No.:1196991-13-5
Molecular Formula:C₂₆H₂₉ClN₈O₄
Molecular Weight:553.02
Hs Code.:

(Z)-2-((2-amino-4-chloro-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-6-oxo-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-5-ylidene)methyl)-N-(4-hydroxycyclohexyl)-1H-imidazole-4-carboxamide

Synonyms:(Z)-2-((2-amino-4-chloro-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-6-oxo-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-5-ylidene)methyl)-N-(4-hydroxycyclohexyl)-1H-imidazole-4-carboxamide

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Chemical Property of (Z)-2-((2-amino-4-chloro-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-6-oxo-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-5-ylidene)methyl)-N-(4-hydroxycyclohexyl)-1H-imidazole-4-carboxamide

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Technology Process of (Z)-2-((2-amino-4-chloro-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-6-oxo-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-5-ylidene)methyl)-N-(4-hydroxycyclohexyl)-1H-imidazole-4-carboxamide

There total 10 articles about (Z)-2-((2-amino-4-chloro-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-6-oxo-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-5-ylidene)methyl)-N-(4-hydroxycyclohexyl)-1H-imidazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 2-((E)-(2-amino-4-chloro-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-6-oxo-6,7-dihydropyrrolo[2,3-d]pyrimidin-5-ylidene)methyl)-N-((1S,4S)-4-(tert-butyldimethylsilyloxy)cyclohexyl)-1H-imidazole-4-carboxamide

: 1196991-13-5
(Z)-2-((2-amino-4-chloro-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-6-oxo-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-5-ylidene)methyl)-N-(4-hydroxycyclohexyl)-1H-imidazole-4-carboxamide

Guidance literature:: With trifluoroacetic acid; In tetrahydrofuran; water; at 20 ℃; for 0.5h;

Reference yield:

: 7459-46-3
triethyl 1,1,2-ethanetricarboxylate

: 1196991-13-5
(Z)-2-((2-amino-4-chloro-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-6-oxo-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-5-ylidene)methyl)-N-(4-hydroxycyclohexyl)-1H-imidazole-4-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / ethanol / 0 - 20 °C

1.2: -10 - 20 °C / Reflux

2.1: benzyltrimethylammonium chloride; N,N-dimethyl-aniline; trichlorophosphate / acetonitrile / 80 °C / Reflux

3.1: potassium tert-butylate; N-ethyl-N,N-diisopropylamine / tert-butyl alcohol

3.2: 20 h / Reflux

4.1: butan-1-ol / Reflux

5.1: piperidine / ethanol / 12 h / 20 °C

6.1: trifluoroacetic acid / tetrahydrofuran; water / 0.5 h / 20 °C

With potassium tert-butylate; benzyltrimethylammonium chloride; sodium hydride; N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trichlorophosphate; piperidine; In tetrahydrofuran; ethanol; water; acetonitrile; tert-butyl alcohol; butan-1-ol;

Reference yield:

: 5-(tert-butyl) 2-ethyl 1H-imidazole-2,5-dicarboxylate

: 1196991-13-5
(Z)-2-((2-amino-4-chloro-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-6-oxo-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-5-ylidene)methyl)-N-(4-hydroxycyclohexyl)-1H-imidazole-4-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: trifluoroacetic acid / dichloromethane / 12 h / 20 °C

2: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 20 °C

4: manganese(IV) oxide / dichloromethane / 0.2 h / 20 °C

5: piperidine / ethanol / 12 h / 20 °C

6: trifluoroacetic acid / tetrahydrofuran; water / 0.5 h / 20 °C

With manganese(IV) oxide; lithium aluminium tetrahydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; piperidine; In tetrahydrofuran; ethanol; dichloromethane; water;