tert-butyl (R)-3-((3aR,5R,6S,6aR)-tetrahydro-6-methoxy-2,2-dimethylfuro[3,2-d][1,3]dioxol-5-yl)-3-(4-methoxyphenyl)propylcarbamate

Base Information

Chemical Name:tert-butyl (R)-3-((3aR,5R,6S,6aR)-tetrahydro-6-methoxy-2,2-dimethylfuro[3,2-d][1,3]dioxol-5-yl)-3-(4-methoxyphenyl)propylcarbamate
CAS No.:889662-96-8
Molecular Formula:C₂₃H₃₅NO₇
Molecular Weight:437.533
Hs Code.:

Synonyms:tert-butyl (R)-3-((3aR,5R,6S,6aR)-tetrahydro-6-methoxy-2,2-dimethylfuro[3,2-d][1,3]dioxol-5-yl)-3-(4-methoxyphenyl)propylcarbamate

Suppliers and Price of tert-butyl (R)-3-((3aR,5R,6S,6aR)-tetrahydro-6-methoxy-2,2-dimethylfuro[3,2-d][1,3]dioxol-5-yl)-3-(4-methoxyphenyl)propylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl (R)-3-((3aR,5R,6S,6aR)-tetrahydro-6-methoxy-2,2-dimethylfuro[3,2-d][1,3]dioxol-5-yl)-3-(4-methoxyphenyl)propylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl (R)-3-((3aR,5R,6S,6aR)-tetrahydro-6-methoxy-2,2-dimethylfuro[3,2-d][1,3]dioxol-5-yl)-3-(4-methoxyphenyl)propylcarbamate

There total 8 articles about tert-butyl (R)-3-((3aR,5R,6S,6aR)-tetrahydro-6-methoxy-2,2-dimethylfuro[3,2-d][1,3]dioxol-5-yl)-3-(4-methoxyphenyl)propylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 889662-95-7
(R)-3-((3aR,5R,6S,6aR)-tetrahydro-6-methoxy-2,2-dimethylfuro[3,2-d][1,3]dioxol-5-yl)-3-(4-methoxyphenyl)propan-1-amine

: 24424-99-5
di-tert-butyl dicarbonate

: 889662-96-8
tert-butyl (R)-3-((3aR,5R,6S,6aR)-tetrahydro-6-methoxy-2,2-dimethylfuro[3,2-d][1,3]dioxol-5-yl)-3-(4-methoxyphenyl)propylcarbamate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1021/jo052418r

Reference yield:

: 889662-74-2
(S)-((3aR,5R,6S,6aR)-tetrahydro-6-methoxy-2,2-dimethylfuro[2,3-d][1,3]dioxol-5-yl)(4-methoxyphenyl)methanol

: 889662-96-8
tert-butyl (R)-3-((3aR,5R,6S,6aR)-tetrahydro-6-methoxy-2,2-dimethylfuro[3,2-d][1,3]dioxol-5-yl)-3-(4-methoxyphenyl)propylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 75 percent / ZrCl₄ / acetonitrile / 0.67 h / 20 °C

2.1: ozone / CH₂Cl₂ / -78 °C

2.2: Me₂S / CH₂Cl₂ / 1 h / 25 °C

3.1: MgSO₄ / CH₂Cl₂ / 10 h / 20 °C

4.1: 0.86 g / NaBH₄ / methanol / 3 h / 20 °C

5.1: H₂ / Pd-C / methanol / 12 h / 20 °C

6.1: 86 percent / Et₃N / tetrahydrofuran / 2 h / 20 °C

With sodium tetrahydroborate; hydrogen; zirconium(IV) chloride; magnesium sulfate; ozone; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1021/jo052418r

Reference yield:

: 889662-80-0
(3aR,5R,6S,6aR)-tetrahydro-6-methoxy-5-((R)-1-(4-methoxyphenyl)but-3-enyl)-2,2-dimethylfuro[3,2-d][1,3]dioxol

: 889662-96-8
tert-butyl (R)-3-((3aR,5R,6S,6aR)-tetrahydro-6-methoxy-2,2-dimethylfuro[3,2-d][1,3]dioxol-5-yl)-3-(4-methoxyphenyl)propylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: ozone / CH₂Cl₂ / -78 °C

1.2: Me₂S / CH₂Cl₂ / 1 h / 25 °C

2.1: MgSO₄ / CH₂Cl₂ / 10 h / 20 °C

3.1: 0.86 g / NaBH₄ / methanol / 3 h / 20 °C

4.1: H₂ / Pd-C / methanol / 12 h / 20 °C

5.1: 86 percent / Et₃N / tetrahydrofuran / 2 h / 20 °C

With sodium tetrahydroborate; hydrogen; magnesium sulfate; ozone; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo052418r