3-(1,4'-bipiperidin-1'-ylmethyl)-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

Base Information

Chemical Name:3-(1,4'-bipiperidin-1'-ylmethyl)-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide
CAS No.:1336960-17-8
Molecular Formula:C₃₇H₃₉F₃N₄O
Molecular Weight:612.738
Hs Code.:

Synonyms:3-(1,4'-bipiperidin-1'-ylmethyl)-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

Suppliers and Price of 3-(1,4'-bipiperidin-1'-ylmethyl)-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-(1,4'-bipiperidin-1'-ylmethyl)-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-(1,4'-bipiperidin-1'-ylmethyl)-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

There total 7 articles about 3-(1,4'-bipiperidin-1'-ylmethyl)-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 3-(1,4'-bipiperidin-1'-ylmethyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid hydrochloride

: 41049-53-0,773012-60-5
1-phenylcyclopropylamine

: 1336960-17-8
3-(1,4'-bipiperidin-1'-ylmethyl)-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 1533-03-5
3-(trifluoromethyl)propiophenone

: 1336960-17-8
3-(1,4'-bipiperidin-1'-ylmethyl)-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hydroxide / ethanol; water / 0.25 h

1.2: 1 h / Reflux

1.3: pH 3

2.1: thionyl chloride / 2 h / Reflux

2.2: 0.17 h

3.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 16 h / Reflux

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

5.1: hydrogenchloride; water / 2 h / Reflux

6.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With hydrogenchloride; N-Bromosuccinimide; thionyl chloride; water; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; dibenzoyl peroxide; In tetrachloromethane; ethanol; dichloromethane; water;

Reference yield:

: 91-56-5,1186480-61-4,84788-92-1
indole-2,3-dione

: 1336960-17-8
3-(1,4'-bipiperidin-1'-ylmethyl)-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hydroxide / ethanol; water / 0.25 h

1.2: 1 h / Reflux

1.3: pH 3

2.1: thionyl chloride / 2 h / Reflux

2.2: 0.17 h

3.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 16 h / Reflux

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

5.1: hydrogenchloride; water / 2 h / Reflux

6.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With hydrogenchloride; N-Bromosuccinimide; thionyl chloride; water; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; dibenzoyl peroxide; In tetrachloromethane; ethanol; dichloromethane; water;