(R)-4-(4-hydroxy-2-oxo-2H-chromen-3-yl)-2-oxo-4-phenylbutyric acid ethyl ester

Base Information

Chemical Name:(R)-4-(4-hydroxy-2-oxo-2H-chromen-3-yl)-2-oxo-4-phenylbutyric acid ethyl ester
CAS No.:1228363-07-2
Molecular Formula:C₂₁H₁₈O₆
Molecular Weight:366.37
Hs Code.:

Synonyms:(R)-4-(4-hydroxy-2-oxo-2H-chromen-3-yl)-2-oxo-4-phenylbutyric acid ethyl ester

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Chemical Property of (R)-4-(4-hydroxy-2-oxo-2H-chromen-3-yl)-2-oxo-4-phenylbutyric acid ethyl ester

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Technology Process of (R)-4-(4-hydroxy-2-oxo-2H-chromen-3-yl)-2-oxo-4-phenylbutyric acid ethyl ester

There total 3 articles about (R)-4-(4-hydroxy-2-oxo-2H-chromen-3-yl)-2-oxo-4-phenylbutyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1076-38-6,92395-12-5
4-hydroxy[1]benzopyran-2-one

: 55629-96-4,55674-14-1,17451-20-6
ethyl 4-phenyl-2-oxobut-3-enoate

: 1228363-07-2
(R)-4-(4-hydroxy-2-oxo-2H-chromen-3-yl)-2-oxo-4-phenylbutyric acid ethyl ester

Guidance literature:: With C₄₁H₄₂N₂O₃; diethylzinc; In hexane; toluene; at 0 - 20 ℃; for 18h; enantioselective reaction; Inert atmosphere; Schlenk technique;
DOI:10.1021/acs.joc.9b02046

Reference yield:

: 1076-38-6,92395-12-5
4-hydroxy[1]benzopyran-2-one

: 17451-20-6,55674-14-1,55629-96-4
(E)-ethyl-2-oxo-4-phenylbut-3-enoate

: 1228363-07-2
(R)-4-(4-hydroxy-2-oxo-2H-chromen-3-yl)-2-oxo-4-phenylbutyric acid ethyl ester

: (S)-4-(4-hydroxy-2-oxo-2H-chromen-3-yl)-2-oxo-4-phenylbutyric acid ethyl ester

Guidance literature:: With 1-[3,5-bis(trifluoromethyl)phenyl]-3-[(1S,2S)-2-(dimethylamino)cyclohexyl]thiourea; In tetrahydrofuran; at 20 ℃; for 3h; enantioselective reaction;
DOI:10.3998/ark.5550190.0011.922

Reference yield:

: 1076-38-6,92395-12-5
4-hydroxy[1]benzopyran-2-one

: 55629-96-4,55674-14-1,17451-20-6
ethyl 4-phenyl-2-oxobut-3-enoate

: 1228363-07-2
(R)-4-(4-hydroxy-2-oxo-2H-chromen-3-yl)-2-oxo-4-phenylbutyric acid ethyl ester

: (S)-4-(4-hydroxy-2-oxo-2H-chromen-3-yl)-2-oxo-4-phenylbutyric acid ethyl ester

Guidance literature:: With 3-(((1S)-(6-methoxyquinolin-4-yl)((2S,4S,5R)-5-inylquinuclidin-2-yl)methyl)amino)-4-(((R)-1-phenylethyl)amino)cyclobut-3-ene-1,2-dione; In chloroform; at 20 ℃; for 12h; optical yield given as %ee; enantioselective reaction;
DOI:10.1002/chem.201000094