4-[2'-(2-chloro-5-trifluoromethyl-phenoxymethyl)-biphenyl-4-yl]-1-(3-phenyl-propyl)-1H-[1,2,3]triazole

Base Information

Chemical Name:4-[2'-(2-chloro-5-trifluoromethyl-phenoxymethyl)-biphenyl-4-yl]-1-(3-phenyl-propyl)-1H-[1,2,3]triazole
CAS No.:1271724-85-6
Molecular Formula:C₃₁H₂₅ClF₃N₃O
Molecular Weight:548.007
Hs Code.:

Synonyms:4-[2'-(2-chloro-5-trifluoromethyl-phenoxymethyl)-biphenyl-4-yl]-1-(3-phenyl-propyl)-1H-[1,2,3]triazole

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Chemical Property of 4-[2'-(2-chloro-5-trifluoromethyl-phenoxymethyl)-biphenyl-4-yl]-1-(3-phenyl-propyl)-1H-[1,2,3]triazole

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Technology Process of 4-[2'-(2-chloro-5-trifluoromethyl-phenoxymethyl)-biphenyl-4-yl]-1-(3-phenyl-propyl)-1H-[1,2,3]triazole

There total 3 articles about 4-[2'-(2-chloro-5-trifluoromethyl-phenoxymethyl)-biphenyl-4-yl]-1-(3-phenyl-propyl)-1H-[1,2,3]triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1271724-98-1
4-(4-bromo-phenyl)-1-(3-phenyl-propyl)-1H-[1,2,3]triazole

: 849062-11-9
(2-((2-chloro-5-(trifluoromethyl)phenoxy)methyl)phenyl)boronic acid

: 1271724-85-6
4-[2'-(2-chloro-5-trifluoromethyl-phenoxymethyl)-biphenyl-4-yl]-1-(3-phenyl-propyl)-1H-[1,2,3]triazole

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cesium fluoride; In tetrahydrofuran; at 120 ℃; under 12929 Torr; Inert atmosphere; Microwave irradiation;
DOI:10.1021/jm101238d

Reference yield:

: 637-59-2
1-Bromo-3-phenylpropane

: 1271724-85-6
4-[2'-(2-chloro-5-trifluoromethyl-phenoxymethyl)-biphenyl-4-yl]-1-(3-phenyl-propyl)-1H-[1,2,3]triazole

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide; copper(II) sulfate / water; tert-butyl alcohol / 0.5 h / 120 °C / 12929 Torr / Microwave irradiation

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cesium fluoride / tetrahydrofuran / 120 °C / 12929 Torr / Inert atmosphere; Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium azide; copper(II) sulfate; cesium fluoride; In tetrahydrofuran; water; tert-butyl alcohol; 2: Suzuki coupling;
DOI:10.1021/jm101238d

Reference yield:

: 766-96-1
4-bromo-1-ethynylbenzene

: 1271724-85-6
4-[2'-(2-chloro-5-trifluoromethyl-phenoxymethyl)-biphenyl-4-yl]-1-(3-phenyl-propyl)-1H-[1,2,3]triazole

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide; copper(II) sulfate / water; tert-butyl alcohol / 0.5 h / 120 °C / 12929 Torr / Microwave irradiation

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cesium fluoride / tetrahydrofuran / 120 °C / 12929 Torr / Inert atmosphere; Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium azide; copper(II) sulfate; cesium fluoride; In tetrahydrofuran; water; tert-butyl alcohol; 2: Suzuki coupling;
DOI:10.1021/jm101238d