methyl (2E)-5-[N-(3,5-dimethoxyphenyl)-4-methylphenylsulfonamido]-2-pentenoate

Base Information

Chemical Name:methyl (2E)-5-[N-(3,5-dimethoxyphenyl)-4-methylphenylsulfonamido]-2-pentenoate
CAS No.:1431116-02-7
Molecular Formula:C₂₁H₂₅NO₆S
Molecular Weight:419.499
Hs Code.:

Synonyms:methyl (2E)-5-[N-(3,5-dimethoxyphenyl)-4-methylphenylsulfonamido]-2-pentenoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (2E)-5-[N-(3,5-dimethoxyphenyl)-4-methylphenylsulfonamido]-2-pentenoate

Chemical Property:

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Technology Process of methyl (2E)-5-[N-(3,5-dimethoxyphenyl)-4-methylphenylsulfonamido]-2-pentenoate

There total 4 articles about methyl (2E)-5-[N-(3,5-dimethoxyphenyl)-4-methylphenylsulfonamido]-2-pentenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₈H₂₁NO₅S

: 21204-67-1,2605-67-6
methyl (triphenylphosphoranylidene)acetate

: 1431116-02-7
methyl (2E)-5-[N-(3,5-dimethoxyphenyl)-4-methylphenylsulfonamido]-2-pentenoate

Guidance literature:: In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.tet.2013.03.012

Reference yield:

: 146308-17-0
N-(3,5-dimethoxyphenyl)-4-methylbenzenesulfonamide

: 1431116-02-7
methyl (2E)-5-[N-(3,5-dimethoxyphenyl)-4-methylphenylsulfonamido]-2-pentenoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

2.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 20 h / 0 - 20 °C

2.2: 0.5 h / 0 °C

3.1: Dess-Martin periodane / dichloromethane / 1 h / 0 °C / Inert atmosphere

4.1: dichloromethane / 2 h / 20 °C / Inert atmosphere

With sodium hydride; Dess-Martin periodane; 9-bora-bicyclo[3.3.1]nonane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 3.1: |Dess-Martin Oxidation / 4.1: |Wittig Olefination;
DOI:10.1016/j.tet.2013.03.012

Reference yield:

: 1431115-90-0
N-allyl-N-(3,5-dimethoxyphenyl)-4-methylbenzenesulfonamide

: 1431116-02-7
methyl (2E)-5-[N-(3,5-dimethoxyphenyl)-4-methylphenylsulfonamido]-2-pentenoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 20 h / 0 - 20 °C

1.2: 0.5 h / 0 °C

2.1: Dess-Martin periodane / dichloromethane / 1 h / 0 °C / Inert atmosphere

3.1: dichloromethane / 2 h / 20 °C / Inert atmosphere

With Dess-Martin periodane; 9-bora-bicyclo[3.3.1]nonane; In tetrahydrofuran; dichloromethane; 2.1: |Dess-Martin Oxidation / 3.1: |Wittig Olefination;
DOI:10.1016/j.tet.2013.03.012