(2-{2-[5-(trans-4-tert-butyl-cyclohexyloxy)-2,3-dihydro-indol-1-yl]-2-oxo-ethylamino}-ethyl)-phosphonic acid

Base Information

• Chemical Name: (2-{2-[5-(trans-4-tert-butyl-cyclohexyloxy)-2,3-dihydro-indol-1-yl]-2-oxo-ethylamino}-ethyl)-phosphonic acid
• CAS No.: 1266116-48-6
• Molecular Formula: C₂₂H₃₅N₂O₅P
• Molecular Weight: 438.504
• Mol file: 1266116-48-6.mol

Synonyms:(2-{2-[5-(trans-4-tert-butyl-cyclohexyloxy)-2,3-dihydro-indol-1-yl]-2-oxo-ethylamino}-ethyl)-phosphonic acid

Chemical Property of (2-{2-[5-(trans-4-tert-butyl-cyclohexyloxy)-2,3-dihydro-indol-1-yl]-2-oxo-ethylamino}-ethyl)-phosphonic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-{2-[5-(trans-4-tert-butyl-cyclohexyloxy)-2,3-dihydro-indol-1-yl]-2-oxo-ethylamino}-ethyl)-phosphonic acid

There total 8 articles about (2-{2-[5-(trans-4-tert-butyl-cyclohexyloxy)-2,3-dihydro-indol-1-yl]-2-oxo-ethylamino}-ethyl)-phosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

(2-{2-[5-(trans-4-tert-butyl-cyclohexyloxy)-2,3-dihydro-indol-1-yl]-2-oxo-ethylamino}-ethyl)-phosphonic acid diethyl ester (1266116-47-5) → (2-{2-[5-(trans-4-tert-butyl-cyclohexyloxy)-2,3-dihydro-indol-1-yl]-2-oxo-ethylamino}-ethyl)-phosphonic acid (1266116-48-6)

Guidance literature:

With trimethylsilyl bromide; In acetonitrile; at 50 ℃;

Reference yield:

2,3-Dihydro-1H-indol-5-ol (172078-33-0) → (2-{2-[5-(trans-4-tert-butyl-cyclohexyloxy)-2,3-dihydro-indol-1-yl]-2-oxo-ethylamino}-ethyl)-phosphonic acid (1266116-48-6)

Guidance literature:

Multi-step reaction with 6 steps

1: sodium hydrogencarbonate / chloroform / 20 °C

2: caesium carbonate / butanone; tert-butyl alcohol / 100 °C / Sealed tube

3: hydrogenchloride / 1,4-dioxane; tetrahydrofuran / 48 h / 20 °C

4: triethylamine / dichloromethane / 4 h / 0 °C

5: potassium carbonate; lithium bromide / N,N-dimethyl-formamide / 70 °C

6: trimethylsilyl bromide / acetonitrile / 50 °C

With hydrogenchloride; trimethylsilyl bromide; sodium hydrogencarbonate; potassium carbonate; caesium carbonate; triethylamine; lithium bromide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; chloroform; N,N-dimethyl-formamide; acetonitrile; butanone; tert-butyl alcohol;

Reference yield:

tert-butyl 5-hydroxy-2,3-dihydroindole-1-carboxylate (170147-76-9) → (2-{2-[5-(trans-4-tert-butyl-cyclohexyloxy)-2,3-dihydro-indol-1-yl]-2-oxo-ethylamino}-ethyl)-phosphonic acid (1266116-48-6)

Guidance literature:

Multi-step reaction with 5 steps

1: caesium carbonate / butanone; tert-butyl alcohol / 100 °C / Sealed tube

2: hydrogenchloride / 1,4-dioxane; tetrahydrofuran / 48 h / 20 °C

3: triethylamine / dichloromethane / 4 h / 0 °C

4: potassium carbonate; lithium bromide / N,N-dimethyl-formamide / 70 °C

5: trimethylsilyl bromide / acetonitrile / 50 °C

With hydrogenchloride; trimethylsilyl bromide; potassium carbonate; caesium carbonate; triethylamine; lithium bromide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile; butanone; tert-butyl alcohol;

upstream raw materials:

2,3-Dihydro-1H-indol-5-ol

tert-butyl 5-hydroxy-2,3-dihydroindole-1-carboxylate

cis-4-tert-butyl-1-cyclohexanol

methanesulfonic acid 4-tert-butylcyclohexyl ester