3-(5-Hydroxy-4-isopropyl-5-phenyl-2-trifluoromethyl-2,5-dihydro-oxazol-2-yl)-propionic acid tert-butyl ester

Base Information

• Chemical Name: 3-(5-Hydroxy-4-isopropyl-5-phenyl-2-trifluoromethyl-2,5-dihydro-oxazol-2-yl)-propionic acid tert-butyl ester
• CAS No.: 87341-20-6
• Molecular Formula: C₂₀H₂₆F₃NO₄
• Molecular Weight: 401.426

Synonyms:3-(5-Hydroxy-4-isopropyl-5-phenyl-2-trifluoromethyl-2,5-dihydro-oxazol-2-yl)-propionic acid tert-butyl ester

Chemical Property of 3-(5-Hydroxy-4-isopropyl-5-phenyl-2-trifluoromethyl-2,5-dihydro-oxazol-2-yl)-propionic acid tert-butyl ester

Chemical Property:

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SDS file from LookChem

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Technology Process of 3-(5-Hydroxy-4-isopropyl-5-phenyl-2-trifluoromethyl-2,5-dihydro-oxazol-2-yl)-propionic acid tert-butyl ester

There total 4 articles about 3-(5-Hydroxy-4-isopropyl-5-phenyl-2-trifluoromethyl-2,5-dihydro-oxazol-2-yl)-propionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

tert-butyl 3-[5-oxo-4-(propan-2-yl)-2-(trifluoromethyl)-2,5-dihydro-1,3-oxazol-2-yl]propanoate (87341-14-8) + phenylmagnesium bromide → 3-(5-Hydroxy-4-isopropyl-5-phenyl-2-trifluoromethyl-2,5-dihydro-oxazol-2-yl)-propionic acid tert-butyl ester (87341-20-6)

Guidance literature:

In tetrahydrofuran; 0 deg C then warming to 25 deg C;

DOI:10.1016/S0040-4039(00)81929-2

Reference yield:

L-valine (72-18-4,25609-85-2,7004-03-7,921-10-8) → 3-(5-Hydroxy-4-isopropyl-5-phenyl-2-trifluoromethyl-2,5-dihydro-oxazol-2-yl)-propionic acid tert-butyl ester (87341-20-6)

Guidance literature:

Multi-step reaction with 3 steps

2: 80 percent / NEt₃ / CH₂Cl₂ / 1.) -10 deg C, 2.) 25 deg C, 12 h

3: 63 percent / tetrahydrofuran / 0 deg C then warming to 25 deg C

With triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0040-4039(00)81929-2

Reference yield:

tert-Butyl acrylate (1663-39-4,25232-27-3) → 3-(5-Hydroxy-4-isopropyl-5-phenyl-2-trifluoromethyl-2,5-dihydro-oxazol-2-yl)-propionic acid tert-butyl ester (87341-20-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / NEt₃ / CH₂Cl₂ / 1.) -10 deg C, 2.) 25 deg C, 12 h

2: 63 percent / tetrahydrofuran / 0 deg C then warming to 25 deg C

With triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0040-4039(00)81929-2

upstream raw materials:

tert-butyl 3-[5-oxo-4-(propan-2-yl)-2-(trifluoromethyl)-2,5-dihydro-1,3-oxazol-2-yl]propanoate

L-valine

tert-Butyl acrylate

2-trifluoromethyl-4-isopropyl-Δ³-oxazolin-5-one

Downstream raw materials:

5,5,5-trifluoro-4-oxopentanoic acid

3-methyl-1-phenylbutane-1,2-dione

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