Technology Process of trans-1-Iodomethyl-4-(2-tridecenyloxymethyl)benzene
There total 10 articles about trans-1-Iodomethyl-4-(2-tridecenyloxymethyl)benzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
1H-imidazole; iodine; triphenylphosphine;
In
diethyl ether; acetonitrile;
at 25 ℃;
for 1h;
DOI:10.1021/jm9606047
- Guidance literature:
-
Multi-step reaction with 6 steps
1: n-BuLi, hexamethylphosphoramide / tetrahydrofuran / 1 h / 0 °C
2: p-TsOH / methanol / 25 °C
3: LiAlH4 / diethyl ether / 24 h / Heating
4: 1.) NaH / 1.) THF, from 0 deg C to RT, 35 min, 2.) THF, 25 deg C, 12 h
5: 50percent aq. HF / acetonitrile / 0.25 h / Ambient temperature
6: 93 percent / Ph3P, imidazole, I2 / diethyl ether; acetonitrile / 1 h / 25 °C
With
1H-imidazole; N,N,N,N,N,N-hexamethylphosphoric triamide; lithium aluminium tetrahydride; n-butyllithium; hydrogen fluoride; iodine; sodium hydride; toluene-4-sulfonic acid; triphenylphosphine;
In
tetrahydrofuran; methanol; diethyl ether; acetonitrile;
DOI:10.1021/jm9606047
- Guidance literature:
-
Multi-step reaction with 4 steps
1: LiAlH4 / diethyl ether / 24 h / Heating
2: 1.) NaH / 1.) THF, from 0 deg C to RT, 35 min, 2.) THF, 25 deg C, 12 h
3: 50percent aq. HF / acetonitrile / 0.25 h / Ambient temperature
4: 93 percent / Ph3P, imidazole, I2 / diethyl ether; acetonitrile / 1 h / 25 °C
With
1H-imidazole; lithium aluminium tetrahydride; hydrogen fluoride; iodine; sodium hydride; triphenylphosphine;
In
diethyl ether; acetonitrile;
DOI:10.1021/jm9606047
